Evidence map›Paper›PMID 33046548›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Dissecting the Role of GABA Neurons in the VTA

Ewa Galaj, Xiao Han, Hui Shen, Chloe J Jordan, Yi He, Bree Humburg, Guo-Hua Bi, Zheng-Xiong Xi

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
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  7. Cannabinoid CB1 receptor and mu-opioid receptor interaction: new insights from conditional knockout mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  17. Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  18. ESG-1-60 and ESG-1-61: Novel dopamine DBritish journal of pharmacology · 2025
    Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ewa GalajAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224.ORCID 0000-0002-7180-4378
Xiao HanAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224.
Hui ShenSynaptic Plasticity Section, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224.
Chloe J JordanAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224.
Yi HeAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224.
Bree HumburgAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224.
Guo-Hua BiAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224.
Zheng-Xiong XiAddiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224 zxi@mail.nih.gov.ORCID 0000-0001-6482-8104
National Institute on Drug Abuse · US

Funding

Cannabinoid CB1 and CB2 receptors and drug abuseZIADA000633 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI XI, ZHENG-XIONG · 2023 to 2025
$3.1M
Central CB2 Cannabinoid ReceptorsZIADA000620 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI NEWMAN, AMY HAUCK · 2017 to 2019
$860k
Intramural NIH HHS ZIA DA000620Intramural NIH HHS ZIA DA000633
6 · The paper itself

Abstract

Opioid reward has traditionally been thought to be mediated by GABA-induced disinhibition of dopamine (DA) neurons in the VTA. However, direct behavioral evidence supporting this hypothesis is still lacking. In this study, we found that the μ opioid receptor (MOR) gene,

Indexed as

RewardAnimalsCuesDopaminergic NeuronsExtinction, PsychologicalFemaleGABAergic NeuronsHeroinMaleMesencephalonMiceMice, Inbred C57BLNarcoticsNeuronsOptogeneticsRatsHeroinNarcoticsOprm1 protein, ratReceptors, Opioid, muGABAheroinrewardsubstantia nigra pars reticulataVTAμ opioid receptor

Identifiers

PMID33046548
PMCPMC7659457
OpenAlexW3091989781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.