ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Multivariate Lesion-Behavior Mapping of General Cognitive Ability and Its Psychometric Constituents.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Cognition disconnected: the influence of domain-general cognition (g) in lesion-deficit mapping.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- A clinical neuroimaging platform for rapid, automated lesion detection and personalized post-stroke outcome prediction.NPJ digital medicine · 2026Article
- Identification of Brain Regions and Networks Critical to Poststroke Cognitive Impairment Through Lesion-symptom and Lesion Network Analyses.Translational stroke research · 2026Article
- Lesions involving the insula are associated with reduced appetite and weight loss.Brain communications · 2026Article
- Acute post-stroke cognitive test performance predicts one-year functional independence.medRxiv : the preprint server for health sciences · 2025Article
- Cognition Disconnected: The Influence of Domain-General Cognition (g) in Lesion-Deficit Mapping.bioRxiv : the preprint server for biology · 2025Article
- An Activation Likelihood Estimation Meta-Analysis of How Language Balance Impacts the Neural Basis of Bilingual Language Control.Brain sciences · 2025Review
- Article
- Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.Brain : a journal of neurology · 2024Article
- Cortical and white matter substrates supporting visuospatial working memory.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- The role of gender in cognitive outcomes from stroke.Journal of the International Neuropsychological Society : JINS · 2023Article
- Localization of a Medial Temporal Lobe-Precuneus Network for Time Orientation.Annals of neurology · 2023Article
- Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience.Brain : a journal of neurology · 2023Article
- White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control.Nature communications · 2023Article
- Graph lesion-deficit mapping of fluid intelligence.Brain : a journal of neurology · 2023Article
- A multi-faceted role of dual-state dopamine signaling in working memory, attentional control, and intelligence.Frontiers in behavioral neuroscience · 2023Review
- Central precuneus lesions are associated with impaired executive function.Brain structure & function · 2022Article
- Depression symptoms in neurological patients: A survey of a large cohort of patients with focal brain lesions.Journal of clinical and experimental neuropsychology · 2022Article
- Post-stroke outcomes predicted from multivariate lesion-behaviour and lesion network mapping.Brain : a journal of neurology · 2022Article
- Lesions in different prefrontal sectors are associated with different types of acquired personality disturbances.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Observational
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7 authors.
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Abstract
General cognitive ability, or general intelligence (g), is central to cognitive science, yet the processes that constitute it remain unknown, in good part because most prior work has relied on correlational methods. Large-scale behavioral and neuroanatomical data from neurologic patients with focal brain lesions can be leveraged to advance our understanding of the key mechanisms of g, as this approach allows inference on the independence of cognitive processes along with elucidation of their respective neuroanatomical substrates. We analyzed behavioral and neuroanatomical data from 402 humans (212 males; 190 females) with chronic, focal brain lesions. Structural equation models (SEMs) demonstrated a psychometric isomorphism between g and working memory in our sample (which we refer to as g/Gwm), but not between g and other cognitive abilities. Multivariate lesion-behavior mapping analyses indicated that g and working memory localize most critically to a site of converging white matter tracts deep to the left temporo-parietal junction. Tractography analyses demonstrated that the regions in the lesion-behavior map of g/Gwm were primarily associated with the arcuate fasciculus. The anatomic findings were validated in an independent cohort of acute stroke patients (
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