Evidence map›Paper›PMID 33046533›Full record

ArticleMolecular and cellular biology2020

A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit.

Melissa A Mefford, Evan P Hass, David C Zappulla

Open access · hybridAbstract read
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Inverse-folding design of yeast telomerase RNA increases activitybioRxiv : the preprint server for biology · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Melissa A MeffordDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA mmefford@moreheadstate.edu david.zappulla@lehigh.edu.
Evan P HassDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
David C ZappullaDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA mmefford@moreheadstate.edu david.zappulla@lehigh.edu.ORCID 0000-0001-8242-3493
Johns Hopkins University · US

Funding

Telomere maintenance by the telomerase RNA-protein complexR01GM118757 · NIGMS · LEHIGH UNIVERSITY · PI ZAPPULLA, DAVID CLIFFORD · 2017 to 2021
$1.7M
NIGMS NIH HHS R01 GM118757
6 · The paper itself

Abstract

The telomerase ribonucleoprotein (RNP) counters the chromosome end replication problem, completing genome replication to prevent cellular senescence in yeast, humans, and most other eukaryotes. The telomerase RNP core enzyme is composed of a dedicated RNA subunit and a reverse transcriptase (telomerase reverse transcriptase [TERT]). Although the majority of the 1,157-nucleotide (nt)

Indexed as

Base PairingBase SequenceBinding SitesDNA ReplicationNucleic Acid ConformationProtein BindingProtein SubunitsRibonucleoproteinsRNASaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTelomeraseTelomereProtein SubunitsRibonucleoproteinsRNASaccharomyces cerevisiae ProteinsTelomerasetelomerase RNARNARNPsenescencetelomerasetelomerase RNAtelomereTERTTLC1two-hybrid screeningyeast

Identifiers

PMID33046533
PMCPMC7685517
OpenAlexW3092398815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.