Evidence map›Paper›PMID 33046522›Full record

ArticleLife science alliance2020

Role of opioid signaling in kidney damage during the development of salt-induced hypertension.

Daria Golosova, Oleg Palygin, Ruslan Bohovyk, Christine A Klemens, Vladislav Levchenko, Denisha R Spires, Elena Isaeva, Ashraf El-Meanawy, Alexander Staruschenko

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. KAmerican journal of physiology. Renal physiology · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. SGLT2 inhibition effect on salt-induced hypertension, RAAS, and NaAmerican journal of physiology. Renal physiology · 2022
    Article
  18. Article
  19. The role of TRPC6 channel in chronic kidney disease.American journal of physiology. Renal physiology · 2022
    Article
  20. Cytoskeleton Rearrangements Modulate TRPC6 Channel Activity in Podocytes.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Daria GolosovaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Oleg PalyginDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-3680-5527
Ruslan BohovykDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Christine A KlemensDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Vladislav LevchenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Denisha R SpiresDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Elena IsaevaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-0587-6322
Ashraf El-MeanawyCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Alexander StaruschenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA staruschenko@mcw.edu.ORCID 0000-0002-5190-8356
Medical College of Wisconsin · US

Funding

ZONISMIDE IN THE TREATMENT OF SEIZURES IN PATIENTSM01RR000058 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI RAO, STEPHEN MARK · 1985 to 2006
$19.9M
Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Renal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6M
Transport and metabolism in the kidneyI01BX004024 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI STARUSCHENKO, ALEXANDER · 2019 to 2025
–
BLRD VA I01 BX004024NCRR NIH HHS M01 RR000058NHLBI NIH HHS R35 HL135749NHLBI NIH HHS T32 HL134643
6 · The paper itself

Abstract

Opioid use is associated with predictors of poor cardiorenal outcomes. However, little is known about the direct impact of opioids on podocytes and renal function, especially in the context of hypertension and CKD. We hypothesize that stimulation of opioid receptors (ORs) contributes to dysregulation of intracellular calcium ([Ca

Indexed as

Analgesics, OpioidAnimalsCalciumHumansHypertensionKidneyKidney DiseasesKidney GlomerulusMalePiperidinesPodocytesPyrrolidinesRatsRats, Inbred DahlSignal TransductionSodium Chloride, Dietary1-(3,4-dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidineAnalgesics, OpioidCalciumPiperidinesPyrrolidinesSodium Chloride, DietaryTRPC6 Cation ChannelTRPC Cation Channels

Identifiers

PMID33046522
PMCPMC7556751
OpenAlexW3092502691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.