Evidence map›Paper›PMID 33046476›Full record

ArticleBMJ open2020

Understanding pathways to inequalities in child mental health: a counterfactual mediation analysis in two national birth cohorts in the UK and Denmark.

Eric Tc Lai, Daniela K Schlüter, Theis Lange, Viviane Straatmann, Anne-Marie Nybo Andersen, Katrine Strandberg-Larsen, David Taylor-Robinson

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 4 countries.

Eric Tc LaiInstitute of Population Health Sciences, University of Liverpool, Liverpool, Merseyside, UK etcl@liverpool.ac.uk.ORCID 0000-0002-1229-9471
Daniela K SchlüterInstitute of Population Health Sciences, University of Liverpool, Liverpool, Merseyside, UK.
Theis LangeSection of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Viviane StraatmannInstitute of Population Health Sciences, University of Liverpool, Liverpool, Merseyside, UK.
Anne-Marie Nybo AndersenSection of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4296-8488
Katrine Strandberg-LarsenSection of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
David Taylor-RobinsonInstitute of Population Health Sciences, University of Liverpool, Liverpool, Merseyside, UK.
University of Copenhagen · DKUniversity of Liverpool · GB

Funding

Medical Research Council G0802448Medical Research Council MR/P008577/1
6 · The paper itself

Abstract

objectivesWe assessed social inequalities in child mental health problems (MHPs) and how they are mediated by perinatal factors, childhood illness and maternal mental health in two national birth cohorts.

designLongitudinal cohort study

settingWe used data from the UK Millennium Cohort Study and the Danish National Birth Cohort. PRIMARY AND SECONDARY OUTCOME MEASURES: We applied causal mediation analysis to longitudinal cohort data. Socioeconomic conditions (SECs) at birth were measured by maternal education. Our outcome was child MHPs measured by the Strength and Difficulty Questionnaire at age 11. We estimated natural direct, indirect and total effects (TEs) of SECs on MHPs. We calculated the proportion mediated (PM) via three blocks of mediators-perinatal factors (smoking/alcohol use during pregnancy, birth weight and gestational age), childhood illness and maternal mental health.

resultsAt age 11 years, 9% of children in the UK and 3.8% in Denmark had MHPs. Compared with high SECs, children in low SECs had a higher risk of MHPs (relative risk (RR)=4.3, 95% CI 3.3 to 5.5 in the UK, n=13 112; and RR=6.2, 95% CI 4.9 to 7.8 in Denmark, n=35 764). In the UK, perinatal factors mediated 10.2% (95% CI 4.5 to 15.9) of the TE, and adding maternal mental health tripled the PM to 32.2% (95% CI 25.4 to 39.1). In Denmark, perinatal factors mediated 16.5% (95% CI 11.9 to 21.1) of the TE, and including maternal mental health increased the PM to 16.9% (95% CI 11.2 to 22.6). Adding childhood illness made little difference in either country.

conclusionSocial inequalities in child mental health are partially explained by perinatal factors in the UK and Denmark. Maternal mental health partially explained inequalities in the UK but not in Denmark.

Indexed as

Health Status DisparitiesMental HealthSocial Determinants of HealthAdultChildCohort StudiesDenmarkFemaleHumansMaleMediation AnalysisPregnancyUnited Kingdomepidemiologymental healthsocial medicine

Identifiers

PMID33046476
PMCPMC7552869
OpenAlexW3092137057

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.