Evidence map›Paper›PMID 33046455›Full record

ReviewDevelopment (Cambridge, England)2020

The twists and turns of left-right asymmetric gut morphogenesis.

Julia Grzymkowski, Brent Wyatt, Nanette Nascone-Yoder

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Mapping Shroom3 expression across the adult mouse.Gene expression patterns : GEP · 2025
    Article
  3. Article
  4. Dynamics of multicellular swirling on micropatterned substrates.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Julia GrzymkowskiDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Brent WyattDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Nanette Nascone-YoderDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA nmnascon@ncsu.edu.ORCID 0000-0003-1301-5298
North Carolina State University · US

Funding

TRAINING IN BIOCHEMICAL AND ENVIRONMENTAL TOXICOLOGYT32ES007046 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Seth William Kullman · 1985 to 2026
$5.1M
NC STATE MOLECULAR BIOTECHNOLOGY TRAINING PROGRAM (MBTP)T32GM133366 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Jason M. Haugh, Robert M Kelly · 2020 to 2026
$3.3M
Ahead of the Curve: Mechanisms of Left-Right Asymmetric Stomach MorphogenesisR01HD095937 · NICHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI NASCONE-YODER, NANETTE M · 2018 to 2022
$1.5M
NICHD NIH HHS R01 HD095937NIEHS NIH HHS T32 ES007046NIGMS NIH HHS T32 GM133366
6 · The paper itself

Abstract

Many organs develop left-right asymmetric shapes and positions that are crucial for normal function. Indeed, anomalous laterality is associated with multiple severe birth defects. Although the events that initially orient the left-right body axis are beginning to be understood, the mechanisms that shape the asymmetries of individual organs remain less clear. Here, we summarize new evidence challenging century-old ideas about the development of stomach and intestine laterality. We compare classical and contemporary models of asymmetric gut morphogenesis and highlight key unanswered questions for future investigation.

Indexed as

AnimalsBody PatterningGastrointestinal MicrobiomeGene Expression Regulation, DevelopmentalHumansMorphogenesisSignal TransductionGut tubeIntestineLateralityLeft-right asymmetryMorphogenesisStomach

Identifiers

PMID33046455
PMCPMC7578356
OpenAlexW3092099252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.