Evidence map›Paper›PMID 33046447›Full record

ArticleAnnals of the rheumatic diseases2021

Age-based (<65 vs ≥65 years) incidence of infections and serious infections with tofacitinib versus biological DMARDs in rheumatoid arthritis clinical trials and the US Corrona RA registry.

Kevin L Winthrop, Gustavo Citera, David Gold, Dan Henrohn, Carol A Connell, Andrea B Shapiro, Harry Shi, Alina M Onofrei, Dimitrios A Pappas, Hendrik Schulze-Koops

Open access · hybridAbstract readLetter
In one paragraph

Article in Annals of the rheumatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Selective JAK-Inhibitors in Spondyloarthritis.Mediterranean journal of rheumatology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs.Clinical, cosmetic and investigational dermatology · 2023
    Review
  11. The infection risks of JAK inhibition.Expert review of clinical immunology · 2022
    Article
  12. Review
  13. User's guide to JAK inhibitors in inflammatory bowel disease.Current research in pharmacology and drug discovery · 2022
    Review
  14. Clinical characteristics of ulcerative colitis in elderly patients.JGH open : an open access journal of gastroenterology and hepatology · 2021
    Review
  15. Article
  16. Review
  17. Tofacitinib: Real-World Data and Treatment Persistence in Rheumatoid Arthritis.Open access rheumatology : research and reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 5 countries.

Kevin L WinthropDivision of Infectious Diseases, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-3892-6947
Gustavo CiteraSection of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina.
David GoldPfizer Inc, Montreal, Quebec, Canada David.Gold@pfizer.com.
Dan HenrohnPfizer Inc, Sollentuna, Sweden.
Carol A ConnellPfizer Inc, Groton, Connecticut, USA.
Andrea B ShapiroPfizer Inc, Peapack, New Jersey, USA.
Harry ShiPfizer Inc, Collegeville, Pennsylvania, USA.
Alina M OnofreiCorrona LLC, Waltham, Massachusetts, USA.
Dimitrios A PappasDepartment of Medicine, Columbia University, New York, New York, USA.ORCID 0000-0001-8338-027X
Hendrik Schulze-KoopsDivision of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, University of Munich, Munich, Bayern, Germany.ORCID 0000-0002-1681-491X
Pfizer (United States) · USColumbia University · USInstituto Nacional de Rehabilitación Psicofísica · AROregon Health & Science University · USPfizer (Canada) · CAPfizer (Sweden) · SEUniversität Bayern · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

RegistriesAdalimumabAgedAge FactorsAntirheumatic AgentsArthritis, RheumatoidBiological ProductsFemaleHumansIncidenceInfectionsJanus Kinase InhibitorsMaleMiddle AgedPiperidinesProportional Hazards ModelsAdalimumabAntirheumatic AgentsBiological ProductsJanus Kinase InhibitorsPiperidinesPyrimidinestofacitinibadalimumabantirheumatic agentsarthritisbiological therapyrheumatoidtumor necrosis factor inhibitors

Identifiers

PMID33046447
PMCPMC7788057
OpenAlexW3092222387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.