Evidence map›Paper›PMID 33046166›Full record

ArticlePsychological medicine2022

A replication study of JTC bias, genetic liability for psychosis and delusional ideation.

Cécile Henquet, Jim van Os, Lotta K Pries, Christian Rauschenberg, Philippe Delespaul, Gunter Kenis, Jurjen J Luykx, Bochao D Lin, Alexander L Richards, Berna Akdede and 36 more

Abstract read
In one paragraph

Article in Psychological medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Can you trust this source? Advice taking in borderline personality disorder.European archives of psychiatry and clinical neuroscience · 2023
    Article
  5. Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Cécile HenquetDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.ORCID 0000-0002-7051-5945
Jim van OsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.
Lotta K PriesDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.
Christian RauschenbergDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.
Philippe DelespaulDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.
Gunter KenisDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.
Jurjen J LuykxDepartment of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Bochao D LinDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Alexander L RichardsMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
Berna AkdedeDepartment of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Tolga BinbayDepartment of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Vesile AltınyazarDepartment of Psychiatry, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Berna YalınçetinDepartment of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey.
Güvem Gümüş-AkayDepartment of Physiology, School of Medicine, Ankara University, Ankara, Turkey.
Burçin CihanDepartment of Psychology, Middle East Technical University, Ankara, Turkey.
Haldun SoygürTurkish Federation of Schizophrenia Associations, Ankara, Turkey.
Halis UlaşDepartment of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey (Discharged by statutory degree No: 701 at 8th July of 2018, because of signing "Peace Petition").
Eylem S CankurtaranGüven Çayyolu Healthcare Campus, Ankara, Turkey.
Semra U KaymakAtatürk Research and Training Hospital Psychiatry Clinic, Ankara, Turkey.
Marina M MihaljevicFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Sanja S PetrovicClinic for Psychiatry CCS, Belgrade, Serbia.
Tijana MirjanicSpecial Hospital for Psychiatric Disorders Kovin, Kovin, Serbia.
Miguel BernardoBarcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Gisela MezquidaBarcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Silvia AmorettiBarcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Julio BobesBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Pilar A SaizBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Maria P García-PortillaBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Julio SanjuanBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Eduardo J AguilarBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Jose L SantosBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Estela Jiménez-LópezBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Manuel ArrojoDepartment of Psychiatry, Instituto de Investigación Sanitaria, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
Angel CarracedoGrupo de Medicina Genómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Gonzalo LópezBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Javier González-PeñasBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Mara ParelladaBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Nadja P MaricFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Cem AtbaşoğluDepartment of Psychiatry, School of Medicine, Ankara University, Ankara, Turkey.
Alp UcokDepartment of Psychiatry, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Köksal AlptekinDepartment of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Meram C SakaDepartment of Psychiatry, School of Medicine, Ankara University, Ankara, Turkey.
Celso ArangoBiomedical Research Networking Centre in Mental Health (CIBERSAM), Spain.
Michael O'DonovanMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
Bart P F RuttenDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.
Sinan GülöksüzDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.

Funding

Medical Research Council G08005009Medical Research Council MR/L010305/1
6 · The paper itself

Abstract

backgroundThis study attempted to replicate whether a bias in probabilistic reasoning, or 'jumping to conclusions'(JTC) bias is associated with being a sibling of a patient with schizophrenia spectrum disorder; and if so, whether this association is contingent on subthreshold delusional ideation.

methodsData were derived from the EUGEI project, a 25-centre, 15-country effort to study psychosis spectrum disorder. The current analyses included 1261 patients with schizophrenia spectrum disorder, 1282 siblings of patients and 1525 healthy comparison subjects, recruited in Spain (five centres), Turkey (three centres) and Serbia (one centre). The beads task was used to assess JTC bias. Lifetime experience of delusional ideation and hallucinatory experiences was assessed using the Community Assessment of Psychic Experiences. General cognitive abilities were taken into account in the analyses.

resultsJTC bias was positively associated not only with patient status but also with sibling status [adjusted relative risk (aRR) ratio : 4.23 CI 95% 3.46-5.17 for siblings and aRR: 5.07 CI 95% 4.13-6.23 for patients]. The association between JTC bias and sibling status was stronger in those with higher levels of delusional ideation (aRR interaction in siblings: 3.77 CI 95% 1.67-8.51, and in patients: 2.15 CI 95% 0.94-4.92). The association between JTC bias and sibling status was not stronger in those with higher levels of hallucinatory experiences.

conclusionsThese findings replicate earlier findings that JTC bias is associated with familial liability for psychosis and that this is contingent on the degree of delusional ideation but not hallucinations.

Indexed as

Psychotic DisordersSchizophreniaBiasDecision MakingDelusionsHallucinationsHumansCognitiondelusionsfamilyjumping to conclusionsneuropsychologypsychosisreasoning

Identifiers

PMID33046166
PMCPMC9280279

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