ArticleGenome medicine2020
The aging mouse microbiome has obesogenic characteristics.
Article in Genome medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MetaPhlAn 4 profiling of unknown species-level genome bins improves the characterization of diet-associated microbiome changes in mice.Cell reports · 2023Pooled it
- Links between bone fractures and the gut microbiota.Nature reviews. Endocrinology · 2026Review
- rTg4510 Tauopathy Mice Exhibit Non-Spatial Memory Deficits Prevented by Doxycycline Treatment.Brain sciences · 2025Article
- GIMIC: smoothed graph-image representation of microbiome samples induce an optimal distance.Genome biology · 2025Article
- Modelling the ageing dependence of cancer evolutionary trajectories.Nature reviews. Cancer · 2025Review
- The microbiome is associated with obesity-related metabolome signature in the process of aging.NPJ biofilms and microbiomes · 2025Article
- Article
- Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.Mucosal immunology · 2025Review
- Gut microbiota variations over the lifespan and longevity in rabbit's maternal lines.Scientific reports · 2025Article
- Transcriptomic and lipidomic analysis of aging-associated inflammatory signature in mouse liver.Inflammation and regeneration · 2025Article
- Maternal dysbiosis produces long-lasting behavioral changes in offspring.Molecular psychiatry · 2025Article
- Article
- Aging amplifies a gut microbiota immunogenic signature linked to heightened inflammation.Aging cell · 2024Article
- Review
- Long term methionine restriction: Influence on gut microbiome and metabolic characteristics.Aging cell · 2024Article
- Gut microbiome-metabolome interactions predict host condition.Microbiome · 2024Article
- Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.JCI insight · 2024Article
- Multi-omics insights implicate the remodeling of the intestinal structure and microbiome in aging.Frontiers in genetics · 2024Article
- Article
- Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring aging, there is a physiological decline, an increase of morbidity and mortality, and a natural change in the gut microbiome. In this study, we investigated the influence of the gut microbiome on different metabolic parameters in adult and aged mice.
methodsFecal and blood samples from adult (n = 42, 100-300 days) and aging (n = 32, 550-750 days) mice were collected. Microbiome analysis was done using QIIME2. Mouse weight and body composition were measured using NMR, and insulin and leptin levels in the blood were measured with Mouse Adipokine Magnetic Bead Panel kit. Fecal microbiota transplantation experiments from adult and aged mice into young germ-free mice were carried out in order to examine the effect of the gut microbiome of adult and aging mice on weight, body composition, insulin, and leptin.
resultsWe demonstrate that the microbiomes from adult and aged mice are distinguishable. We also report changes in metabolic parameters as we observed significantly higher weight and fat mass and low lean mass in aged compared to adult mice along with high insulin and leptin levels in the blood. The transplanted gut microbiome from aged mice transferred part of the phenotypes seen in aged mice. Fat body mass and insulin levels were higher in the mice who received feces from aged mice than mice receiving feces from adult mice. In addition, they consumed more food and had a higher respiratory quotient compared to mice receiving adult feces.
conclusionsWe conclude that aged mice have a gut microbiota with obesogenic characteristics. In addition, the gut bacterial population itself is sufficient to induce some of the manifestations of obesity.
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