ArticleBMC medicine2020
Postpartum plasma metabolomic profile among women with preeclampsia and preterm delivery: implications for long-term health.
Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Ferroptosis-related gene BACH1 is associated with preeclampsia and shows potential as a biomarker.BMC pregnancy and childbirth · 2026Article
- Postpartum metabolomics profile predicts 8-years postdelivery women's subclinical atherosclerosis measures.Scientific reports · 2025Article
- Metabolomic Profiles During and After a Hypertensive Disorder of Pregnancy: The EPOCH Study.International journal of molecular sciences · 2025Article
- Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Association of pregnancy complications and postpartum maternal leukocyte telomeres in two diverse cohorts: a nested case-control study.BMC pregnancy and childbirth · 2024Article
- Maternal Mediterranean-Style Diet Adherence during Pregnancy and Metabolomic Signature in Postpartum Plasma: Findings from the Boston Birth Cohort.The Journal of nutrition · 2024Article
- Article
- The dynamic inflammatory profile of pregnancy can be monitored using a novel lipid-based mass spectrometry technique.Molecular omics · 2023Article
- Effects of ambient particulate exposure on blood lipid levels in hypertension inpatients.Frontiers in public health · 2023Article
- Boston Birth Cohort profile: rationale and study design.Precision nutrition · 2022Article
- Trimethylamine N-Oxide and Its Precursors Are Associated with Gestational Diabetes Mellitus and Pre-Eclampsia in the Boston Birth Cohort.Current developments in nutrition · 2022Article
- Identification of Biomarkers for Preeclampsia Based on Metabolomics.Clinical epidemiology · 2022Review
- Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells.Frontiers in molecular biosciences · 2021Article
- Applications of Multivariate Statistical and Data Mining Analyses to the Search for Biomarkers of Sensorineural Hearing Loss, Tinnitus, and Vestibular Dysfunction.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPreeclampsia and preterm delivery (PTD) are believed to affect women's long-term health including cardiovascular disease (CVD), but the biological underpinnings are largely unknown. We aimed to test whether maternal postpartum metabolomic profiles, especially CVD-related metabolites, varied according to PTD subtypes with and without preeclampsia, in a US urban, low-income multi-ethnic population.
methodsThis study, from the Boston Birth Cohort, included 980 women with term delivery, 79 with medically indicated PTD (mPTD) and preeclampsia, 52 with mPTD only, and 219 with spontaneous PTD (sPTD). Metabolomic profiling in postpartum plasma was conducted by liquid chromatography-mass spectrometry. Linear regression models were used to assess the associations of each metabolite with mPTD with preeclampsia, mPTD only, and sPTD, respectively, adjusting for pertinent covariates. Weighted gene coexpression network analysis was applied to investigate interconnected metabolites associated with the PTD/preeclampsia subgroups. Bonferroni correction was applied to account for multiple testing.
resultsA total of 380 known metabolites were analyzed. Compared to term controls, women with mPTD and preeclampsia showed a significant increase in 36 metabolites, mainly representing acylcarnitines and multiple classes of lipids (diacylglycerols, triacylglycerols, phosphocholines, and lysophosphocholines), as well as a decrease in 11 metabolites including nucleotides, steroids, and cholesteryl esters (CEs) (P < 1.3 × 10
conclusionIn this sample of US high-risk women, PTD/preeclampsia subgroups each showed some unique and shared associations with maternal postpartum plasma metabolites, including those known to be predictors of future CVD. These findings, if validated, may provide new insight into metabolomic alterations underlying clinically observed PTD/preeclampsia subgroups and implications for women's future cardiometabolic health.
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