ArticleBMC cancer2020
Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic molecular biomarkers in chordomas: A systematic review and identification of clinically usable biomarker panels.Frontiers in oncology · 2022Pooled it
- Preoperative Platelet Distribution Width Represents a Novel Prognostic Biomarker in Patients With Nonmetastatic Renal Cell Carcinoma: A Retrospective Clinical Analysis.Frontiers in oncology · 2022Article
- Mean Platelet Volume Enhances the Diagnostic Specificity of PSA for Prostate Cancer.Frontiers in surgery · 2022Article
- Development and validation of a preoperative MRI-based radiomics nomogram to predict progression-free survival in patients with clival chordomas.Frontiers in oncology · 2022Article
- Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5.Cell proliferation · 2021Article
- High Red Cell Distribution Width Independently Predicts Adverse Survival in Patients with Newly Diagnosed Skull Base Chordoma.OncoTargets and therapy · 2021Article
- Development and validation of nomogram based on a novel platelet index score to predict prognosis in patients with renal cell carcinoma.Journal of Cancer · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundIncreasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic role of platelet indices in chordoma patients remain unclear. The aim of the current study was to characterize the prognostic performance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in skull base chordoma patients.
methods187 primary skull base chordoma patients between January 2008 and September 2014 were enrolled in this retrospective study. The optimal cut-off values were determined by X-tile software, and the correlations between PLT, MPV, PDW and clinicopathological features were further analysed. Kaplan-Meier curve and Cox regression analysis were used for survival analysis.
resultsThe values of preoperative PTL, MPV and PDW ranged from 104 to 501 × 10
conclusionsOur data show that elevated MPV and PDW are associated with poor outcomes in skull base chordoma and that PDW may be helpful to identify patients with high risk.
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