Evidence map›Paper›PMID 33045856›Full record

ArticleInternational journal of immunopathology and pharmacology

Occult hepatitis C virus infection in patients with malignant lymphoproliferative disorders.

Abeya A Lotfi, Asmaa E Mohamed, Nahela A Shalaby, Deena S Eissa, Ehab El-Dabaa, Ayman M Sallam, Mahmoud M Kamel, Hisham Abdelaziz, Amal M El-Afifi, Ahmed S Abdel-Moneim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Molecular characterization and antibiotic susceptibility of methicillin-resistantInternational journal of immunopathology and pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Abeya A LotfiClinical and Chemical Pathology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Asmaa E MohamedClinical and Chemical Pathology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Nahela A ShalabyClinical and Chemical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Deena S EissaClinical and Chemical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ehab El-DabaaBiochemistry and Molecular biology department, Theodor Bilharz Research Institute, Giza, Egypt.
Ayman M SallamBiochemistry and Molecular biology department, Theodor Bilharz Research Institute, Giza, Egypt.
Mahmoud M KamelClinical Pathology Department, National Cancer Institute, Cairo University, Giza, Egypt.ORCID https://orcid.org/0000-0001-6264-6921
Hisham AbdelazizClinical Pathology Department, National Cancer Institute, Cairo University, Giza, Egypt.
Amal M El-AfifiDepartment of Clinical hematology and transplantation, Ain shams University, Cairo, Egypt.
Ahmed S Abdel-MoneimMicrobiology Department, College of Medicine, Taif University, Taif, Saudi Arabia.
Theodor Bilharz Research Institute · EGAin Shams University · EGCairo University · EGBeni-Suef University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the link between HCV and malignant lymphoproliferative disorders has been established, the association between occult hepatitis C virus infection and malignant lymphoproliferative disorders remains obscure. The present study intended to identify the possible association between occult HCV infection and malignant lymphoproliferative disorders. Newly diagnosed patients with LPDs were screened for the presence of HCV-RNA in both plasma and PBMCs. PBMCs of the subjects were also, examined by transmission and immuno-electron microscopy. LPD patients showed a high percentage of HCV infection (71.9%): OCI-HCV (37.5%) and HCV (34.38%). Meanwhile, 28.13% of LPD patients did not show any evidence of HCV infection. Ultrastructural examination of PBMCs revealed the presence of intracytoplasmic vacuoles enclosing viral like particles, which were less prominent in occult HCV patients. The possibility of occult HCV should be considered in patients with LPDs which can be helpful in the management of the treatment protocol in order to set up a balance between the control of the tumor progression and minimizing post chemotherapy complications related to HCV infection.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesFemaleHematologic NeoplasmsHepacivirusHepatitis CHumansLeukocytes, MononuclearLymphoproliferative DisordersMaleMicroscopy, Electron, TransmissionMicroscopy, ImmunoelectronMiddle AgedReal-Time Polymerase Chain ReactionRNA, Viralhepatitis C viruslymphoproliferative disordersoccult HCV

Identifiers

PMID33045856
PMCPMC7557643
OpenAlexW3092388146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.