Evidence map›Paper›PMID 33045840›Full record

ArticleAIDS research and human retroviruses2021

Micro RNA Targets in HIV Latency: Insights into Novel Layers of Latency Control.

Ashley I Heinson, Jeongmin Woo, Amey Mukim, Cory H White, Bastiaan Moesker, Alberto Bosque, Celsa A Spina, Christopher H Woelk, Ben D Macarthur, Nadejda Beliakova-Bethell

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Role of p53 in HIV Infection.Current HIV/AIDS reports · 2023
    Review
  5. Review
  6. Review
  7. HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency.Frontiers in cellular and infection microbiology · 2022
    Review
  8. The involvement of microRNAs in HCV and HIV infection.Therapeutic advances in vaccines and immunotherapy · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Ashley I HeinsonFaculty of Medicine, University of Southampton, Southampton, United Kingdom.
Jeongmin WooFaculty of Medicine, University of Southampton, Southampton, United Kingdom.
Amey MukimVA San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, California, USA.
Cory H WhiteFaculty of Medicine, University of Southampton, Southampton, United Kingdom.
Bastiaan MoeskerFaculty of Medicine, University of Southampton, Southampton, United Kingdom.
Alberto BosqueDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, District of Columbia, USA.
Celsa A SpinaVA San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, California, USA.
Christopher H WoelkFaculty of Medicine, University of Southampton, Southampton, United Kingdom.
Ben D MacarthurFaculty of Medicine, University of Southampton, Southampton, United Kingdom.
Nadejda Beliakova-BethellVA San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, California, USA.
University of Southampton · GBGeorge Washington University · USUniversity of California, San Diego · USVA San Diego Healthcare System · USVeterans Medical Research Foundation of San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
Synthetic Molecular Sensors to Target Latently Infected Cells for HIV EradicationR33AI104282 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI LOONEY, DAVID JAMES · 2016 to 2018
$1.3M
HIV reactivation from latency - role of CD4 T cell maturation phenotypeIK2BX002731 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BELIAKOVA-BETHELL, NADEJDA S · 2016 to 2020
–
BLRD VA IK2 BX002731NCATS NIH HHS UL1 TR001442NIAID NIH HHS P30 AI036214NIAID NIH HHS R33 AI104282
6 · The paper itself

Abstract

Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus. Most recently, noncoding genes have been implicated in regulation of HIV expression. In this study, small RNA sequencing was used to profile expression of microRNAs (miRNAs) in a primary CD4

Indexed as

HIV-1HIV InfectionsMicroRNAsRNA, Long NoncodingGene Expression ProfilingHumansVirus LatencyMicroRNAsRNA, Long NoncodingHIV latencymicroRNAmiRNAp53 signalingRNA-Seqsmall RNA sequencing

Identifiers

PMID33045840
PMCPMC7876363
OpenAlexW3092372050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.