ReviewThe Korean journal of internal medicine2021
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease.
Review in The Korean journal of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Urate-lowering effects of losartan: a meta-analysis of randomised controlled trials and target trial emulation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- A metabolomic signatures in hyperuricemia: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2026Pooled it
- Effects of uric acid-lowering therapy (ULT) on renal outcomes in CKD patients with asymptomatic hyperuricemia: a systematic review and meta-analysis.BMC nephrology · 2024Pooled it
- The link between hyperuricemia and diabetes: insights from a quantitative analysis of scientific literature.Frontiers in endocrinology · 2024Pooled it
- Sex-stratified disproportionality signals of adverse events with allopurinol and febuxostat: a retrospective pharmacovigilance analysis of FAERS and EudraVigilance.Clinical rheumatology · 2026Article
- The GPX3-VCAM1 Axis Gates Pro-Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Shell Thickness Regulated Non-Enzymatic Au@AgNanocube Electrochemical Sensor for Sensitive and Simultaneous Analytical Detection of Three Important Kidney Dysfunction Biomarkers.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Cold-Adapted Uric Acid-DegradingMolecules (Basel, Switzerland) · 2026Article
- Advances in the management of gout: From current strategies to emerging therapies.The Journal of international medical research · 2026Review
- Exploration and clinical analysis of the correlation between the triglyceride-glucose index and hyperuricemia in patients with type 2 diabetes: a real-world, retrospective, cross-sectional study with subsequent cohort analysis.BMC endocrine disorders · 2026Article
- The imbalance of Th17/Treg cells exists in asymptomatic hyperuricemia (the early stage of gout).Clinical rheumatology · 2026Article
- Dual Mechanisms of Naru Sanwei Pills in Gout: NLRP3 Inflammasome Inhibition and Uric Acid Regulation.Journal of inflammation research · 2026Article
- Quantity-effect correlation between water intake and serum uric acid in US adults: a cross-sectional study based on NHANES data.Translational andrology and urology · 2025Article
- Hyperuricemia as an Early Indicator of Cardiovascular Risk in the General Population.Journal of clinical medicine · 2025Article
- Identification of age-specific risk factors for hyperuricemia: a machine learning-driven stratified analysis in health examination cohorts.BMC medical informatics and decision making · 2025Article
- Social determinants of health and mortality on hyperuricemia adults in the USA from 2007 to 2016: a national cohort study.BMC public health · 2025Article
- Exploration of the Interrelationship Between Serum Uric Acid, Gout, and Cardiac, Renal, and Metabolic Conditions in Middle Aged and Older People.Journal of the American Heart Association · 2025Article
- Association between obstructive sleep apnea and hyperuricemia/gout in the general population: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- The relationship between albumin-corrected anion gap and hyperuricemia and its role in cardiovascular risk assessment: mediation effect analysis of triglycerides and non-high-density lipoproteins.Frontiers in endocrinology · 2025Article
- Mendelian Randomization Studies: Opening a New Window in the Study of Metabolic Diseases and Chronic Kidney Disease.Endocrine, metabolic & immune disorders drug targets · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Previous research has investigated whether hyperuricemia serves as an independent risk factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally high level of uric acid (UA; i.e., serum urate level > 6.8 mg/dL). Hyperuricemia has been considered a complication of chronic kidney disease (CKD). However, it seems to play a pathogenic role in the progression of renal diseases. There has been increasing focus on the link between hyperuricemia and CKD. The results of randomized controlled trials have implied independent associations between hyperuricemia and the progression of cardiovascular and renal morbidities. These associations may be mediated by renin-angiotensin system activation, nitric oxide synthase inhibition, and macrovascular/microvascular disease development. There remains controversy regarding the use of serum UA level as an indirect index of renal vascular disease. This literature review focuses on the role of asymptomatic hyperuricemia in the progression of CKD, as well as the association between hyperuricemia and cardiovascular disease. It also provides a general overview of the physiological metabolism of UA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.