ArticleNucleic acids research2020
Cross-Inhibitor: a time-sensitive molecular circuit based on DNA strand displacement.
Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- A Localized Scalable DNA Logic Circuit System Based on the DNA Origami Surface.International journal of molecular sciences · 2025Article
- Scalable DNA recognition circuits based on DNA strand displacement.Nanoscale advances · 2024Article
- An Exo III-powered closed-loop DNA circuit architecture for biosensing/imaging.Mikrochimica acta · 2024Article
- Temporal logic circuits implementation using a dual cross-inhibition mechanism based on DNA strand displacement.RSC advances · 2023Article
- Reconfigurable DNA triplex structure for pH responsive logic gates.RSC advances · 2023Article
- Programming DNA Reaction Networks Using Allosteric DNA Hairpins.Biomolecules · 2023Article
- Mapping Temporally Ordered Inputs to Binary Message Outputs with a DNA Temporal Logic Circuit.Nanomaterials (Basel, Switzerland) · 2023Article
- DNA strand displacement based computational systems and their applications.Frontiers in genetics · 2023Review
- Rapid microRNA detection method based on DNA strand displacement for ovarian cancer cells.Journal of Cancer · 2023Article
- DNA-based customized functional modules for signal transformation.Frontiers in chemistry · 2023Review
- Massively Parallel DNA Computing Based on Domino DNA Strand Displacement Logic Gates.ACS synthetic biology · 2022Article
- DNA Strand-Displacement Temporal Logic Circuits.Journal of the American Chemical Society · 2022Article
- An Operational DNA Strand Displacement Encryption Approach.Nanomaterials (Basel, Switzerland) · 2022Article
- Medical Image Protection Algorithm Based on Deoxyribonucleic Acid Chain of Dynamic Length.Frontiers in genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Designing biochemical systems that can be effectively used in diverse fields, including diagnostics, molecular computing and nanomachines, has long been recognized as an important goal of molecular programming and DNA nanotechnology. A key issue in the development of such practical devices on the nanoscale lies in the development of biochemical components with information-processing capacity. In this article, we propose a molecular device that utilizes DNA strand displacement networks and allows interactive inhibition between two input signals; thus, it is termed a cross-inhibitor. More specifically, the device supplies each input signal with a processor such that the processing of one input signal will interdict the signal of the other. Biochemical experiments are conducted to analyze the interdiction performance with regard to effectiveness, stability and controllability. To illustrate its feasibility, a biochemical framework grounded in this mechanism is presented to determine the winner of a tic-tac-toe game. Our results highlight the potential for DNA strand displacement cascades to act as signal controllers and event triggers to endow molecular systems with the capability of controlling and detecting events and signals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.