Evidence map›Paper›PMID 33045741›Full record

ArticleNucleic acids research2021

LncSEA: a platform for long non-coding RNA related sets and enrichment analysis.

Jiaxin Chen, Jian Zhang, Yu Gao, Yanyu Li, Chenchen Feng, Chao Song, Ziyu Ning, Xinyuan Zhou, Jianmei Zhao, Minghong Feng and 9 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Computational Resources for lncRNA Functions and Targetome.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
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  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jiaxin ChenSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Jian ZhangSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Yu GaoSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Yanyu LiSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Chenchen FengSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Chao SongDepartment of Pharmacology, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Ziyu NingSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Xinyuan ZhouSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Jianmei ZhaoSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Minghong FengSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Yuexin ZhangSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Ling WeiSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Qi PanSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Yong JiangSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Fengcui QianSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Junwei HanCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Yongsan YangSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Qiuyu WangSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.
Chunquan LiSchool of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing 163319, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) have been proven to play important roles in transcriptional processes and various biological functions. Establishing a comprehensive collection of human lncRNA sets is urgent work at present. Using reference lncRNA sets, enrichment analyses will be useful for analyzing lncRNA lists of interest submitted by users. Therefore, we developed a human lncRNA sets database, called LncSEA, which aimed to document a large number of available resources for human lncRNA sets and provide annotation and enrichment analyses for lncRNAs. LncSEA supports >40 000 lncRNA reference sets across 18 categories and 66 sub-categories, and covers over 50 000 lncRNAs. We not only collected lncRNA sets based on downstream regulatory data sources, but also identified a large number of lncRNA sets regulated by upstream transcription factors (TFs) and DNA regulatory elements by integrating TF ChIP-seq, DNase-seq, ATAC-seq and H3K27ac ChIP-seq data. Importantly, LncSEA provides annotation and enrichment analyses of lncRNA sets associated with upstream regulators and downstream targets. In summary, LncSEA is a powerful platform that provides a variety of types of lncRNA sets for users, and supports lncRNA annotations and enrichment analyses. The LncSEA database is freely accessible at http://bio.liclab.net/LncSEA/index.php.

Indexed as

Databases, GeneticGene Expression RegulationComputational BiologyData MiningHumansInternetMolecular Sequence AnnotationRegulatory Sequences, Nucleic AcidRNA, Long NoncodingSequence Analysis, RNATranscription FactorsUser-Computer InterfaceRNA, Long NoncodingTranscription Factors

Identifiers

PMID33045741
PMCPMC7778898

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.