ArticleNeuroImage. Clinical2020
Parieto-occipital sulcus widening differentiates posterior cortical atrophy from typical Alzheimer disease.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Visual rating scales of atrophy differentiate sporadic behavioral variant frontotemporal dementia from primary psychiatric disorder: DIPPA study.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Predictor model for mild cognitive impairment in Parkinson's disease using visual rating scales.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- The First Shall Be First: Letter-Position Coding and Spatial Invariance in Two Cases of Attentional Dyslexia.Brain sciences · 2025Article
- Investigating the Impact of Presentation Format on Reading Ability in Posterior Cortical Atrophy: A Case Study.Reports (MDPI) · 2025Article
- Phenotype-specific metabolic patterns in Posterior cortical atrophy and early-onset typical Alzheimer's disease.Annals of nuclear medicine · 2025Article
- Quantifying Brain Atrophy Using a CSF-Focused Segmentation Approach.Dementia and neurocognitive disorders · 2025Article
- Neuroimaging in posterior cortical atrophy: an integrative review for clinicians and radiologists.Frontiers in neurology · 2025Review
- Effects of Route Complexity and Lighting on Route Following in Alzheimer's Disease and Posterior Cortical Atrophy.Brain sciences · 2024Article
- Evaluation of a multimodal diagnostic algorithm for prediction of cognitive impairment in elderly patients with dizziness.Journal of neurology · 2024Article
- Utility of visual rating scales in primary progressive aphasia.Alzheimer's research & therapy · 2024Article
- Predominant right temporal lobe atrophy: Clinical, neuropsychological and structural differences based on amyloid status.European journal of neurology · 2024Article
- Clinical Heterogeneity in Alzheimer's Disease: A Possible New Amnesic Phenotype.Journal of Alzheimer's disease reports · 2024Review
- Research Advancements on the Correlation Between Spontaneous Intracerebral Hemorrhage of Different Etiologies and Imaging Markers of Cerebral Small Vessel Disease.Neuropsychiatric disease and treatment · 2024Review
- Cortical Sulcal Abnormalities Revealed by Sulcal Morphometry in Patients with Chronic and Episodic Migraine.Journal of pain research · 2024Article
- Altered brain structure in preschool-aged children with tetralogy of Fallot.Pediatric research · 2023Article
- Visual atrophy rating scales and amyloid PET status in an Alzheimer's disease clinical cohort.Annals of clinical and translational neurology · 2023Review
- Diencephalic versus Hippocampal Amnesia in Alzheimer's Disease: The Possible Confabulation-Misidentification Phenotype.Journal of Alzheimer's disease : JAD · 2023Article
- Genetic map of regional sulcal morphology in the human brain from UK biobank data.Nature communications · 2022Article
- Diagnosis of Alzheimer's disease: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology.Dementia & neuropsychologia · 2022Article
- Characteristics of Cortical Atrophy and White Matter Lesions Between Dementia With Lewy Bodies and Alzheimer's Disease: A Case-Control Study.Frontiers in neurology · 2021Article
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Abstract
objectivesPosterior Cortical Atrophy (PCA) is an atypical presentation of Alzheimer disease (AD) characterized by atrophy of posterior brain regions. This pattern of atrophy is usually evaluated with Koedam visual rating scale, a score developed to enable visual assessment of parietal atrophy on magnetic resonance imaging (MRI). However, Koedam scale is complex to assess and its utility in the differential diagnosis between PCA and typical AD has not been demonstrated yet. The aim of this study is therefore to spot a simple and reliable MRI element able to differentiate between PCA and typical AD using visual rating scales.
methods15 patients who presented with progressive complex visual disorders and predominant occipitoparietal hypometabolism on PET-FDG were selected from our centre and compared with 30 typical AD patients and 15 healthy subjects. We used previously validated visual rating scales including Koedam scale, which we divided into three major components: posterior cingulate, precuneus and parieto-occipital. Subsequently we validated the results using the automated software Brainvisa Morphologist and Voxel Based Morphometry (VBM).
resultsPatients with PCA, compared to typical AD, showed higher widening of the parieto-occipital sulcus, assessed both with visual rating scales and Brainvisa. In the corresponding areas, the VBM analysis showed an inverse correlation between the results obtained from the visual evaluation scales with the volume of the grey matter and a direct correlation between the same results with the cerebrospinal fluid volume.
conclusionsA visually based rating scale for parieto-occipital sulcus can distinguish Posterior Cortical Atrophy from typical Alzheimer disease.
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