ArticleHearing research2020
Changes in audiometric threshold and frequency selectivity correlate with cochlear histopathology in macaque monkeys with permanent noise-induced hearing loss.
Article in Hearing research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Noise-induced hearing loss delays auditory learning and reduces the influence of acoustic evidence on choice.bioRxiv : the preprint server for biology · 2026Article
- Cortical representation of pitch perception in mice.Communications biology · 2026Article
- Article
- Cochlear histopathology in macaques after noise-induced temporary threshold shifts.Hearing research · 2026Article
- Physiological, Histological, and Cognitive Characterization of a Rhesus Macaque Model of Presbycusis.bioRxiv : the preprint server for biology · 2026Article
- Persistent impairment of spatial hearing and neural binaural interaction after "temporary" noise-induced hearing loss.bioRxiv : the preprint server for biology · 2026Article
- Cortical Representation of Pitch Perception in Mice.bioRxiv : the preprint server for biology · 2025Article
- Auditory decision-making deficits after permanent noise-induced hearing loss.Scientific reports · 2025Article
- Simplified cochlear frequency selectivity measure for sensorineural hearing loss screening: comparison with digit triplet test (DTT) and shortened speech, spatial and qualities of hearing scale (SSQ) questionnaire.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Tinnitus in a Guinea Pig Model.Brain sciences · 2022Article
- An assessment of ambient noise and other environmental variables in a nonhuman primate housing facility.Lab animal · 2022Article
- Evidence of Hearing Loss and Unrelated Toxoplasmosis in a Free-Ranging Harbour Porpoise (Animals : an open access journal from MDPI · 2021Article
- Three psychophysical metrics of auditory temporal integration in macaques.The Journal of the Acoustical Society of America · 2021Article
- Correlations between cochlear pathophysiology and behavioral measures of temporal and spatial processing in noise exposed macaques.Hearing research · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Exposure to loud noise causes damage to the inner ear, including but not limited to outer and inner hair cells (OHCs and IHCs) and IHC ribbon synapses. This cochlear damage impairs auditory processing and increases audiometric thresholds (noise-induced hearing loss, NIHL). However, the exact relationship between the perceptual consequences of NIHL and its underlying cochlear pathology are poorly understood. This study used a nonhuman primate model of NIHL to relate changes in frequency selectivity and audiometric thresholds to indices of cochlear histopathology. Three macaques (one Macaca mulatta and two Macaca radiata) were trained to detect tones in quiet and in noises that were spectrally notched around the tone frequency. Audiograms were derived from tone thresholds in quiet; perceptual auditory filters were derived from tone thresholds in notched-noise maskers using the rounded-exponential fit. Data were obtained before and after a four-hour exposure to a 50-Hz noise centered at 2 kHz at 141 or 146 dB SPL. Noise exposure caused permanent audiometric threshold shifts and broadening of auditory filters at and above 2 kHz, with greater changes observed for the 146-dB-exposed monkeys. The normalized bandwidth of the perceptual auditory filters was strongly correlated with audiometric threshold at each tone frequency. While changes in audiometric threshold and perceptual auditory filter widths were primarily determined by the extent of OHC survival, additional variability was explained by including interactions among OHC, IHC, and ribbon synapse survival. This is the first study to provide within-subject comparisons of auditory filter bandwidths in an animal model of NIHL and correlate these NIHL-related perceptual changes with cochlear histopathology. These results expand the foundations for ongoing investigations of the neural correlates of NIHL-related perceptual changes.
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