ReviewMolecular metabolism2020
The role of exercise-induced peripheral factors in sleep regulation.
Review in Molecular metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05546294 (The Effects of Aerobic Exercise on Sleep Quality, Fatigue, Quality of Life, Depression, Serum BDNF and Irisin Levels in Patients With Rheumatoid Arthritis), which is not on this map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Aerobic Exercise on Sleep Quality, Fatigue, Quality of Life, Depression, Serum BDNF and Irisin Levels in Patients With Rheumatoid Arthritis: A Prospective Randomized Controlled Study
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Dose-response relationship of exercise interventions on sleep quality in patients with depression: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Network meta-analysis and dose-response analysis of exercise on sleep quality and BMI in obese populations.Frontiers in public health · 2026Pooled it
- Exercise interventions to improve sleep quality in university students: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Optimal exercise type and dose to improve sleep quality in older adults: a systematic review and network meta-analysis.BMC geriatrics · 2025Pooled it
- Physical activity and sleep: An updated umbrella review of the 2018 Physical Activity Guidelines Advisory Committee report.Sleep medicine reviews · 2021Pooled it
- Longitudinal associations between exercise duration and sleep quality and poor sleep outcomes among college students: a latent growth curve modeling study.BMC psychology · 2026Article
- Effect of a digital-based integrated exercise and sleep intervention for older adults with depression: study protocol for a stepped-wedge cluster randomized controlled trial.BMC geriatrics · 2026Article
- The synergistic effects of diet and physical activity on sleep quality among Chinese adolescents: A comprehensive cross-sectional study.Global mental health (Cambridge, England) · 2026Article
- The Beauty Sleep to Keep a Healthy Liver.International journal of molecular sciences · 2025Review
- Exercise and sleep health in college students: Efficacy, mechanisms, and implications for practice.World journal of psychiatry · 2025Review
- Aerobic Training-Induced Changes in Sedentary Time, Non-Exercise Physical Activity, and Sleep Among Breast Cancer Survivors and Postmenopausal Women Without Cancer.Healthcare (Basel, Switzerland) · 2025Article
- Improving Sleep Quality to Enhance Athletic Activity-The Role of Nutrition and Supplementation: A Mini-Short Review.Nutrients · 2025Review
- Effects of physical activity on sleep quality among university students: chain mediation between rumination and depression levels.BMC psychiatry · 2025Article
- Sleep duration in middle-aged years of life predicts the age of diagnosis of Parkinson's disease.Sleep medicine: X · 2024Article
- Exercise derived myokine irisin as mediator of cardiorespiratory, metabolic and thermal adjustments during central and peripheral chemoreflex activation.Scientific reports · 2024Article
- Effects on Sleep Quality of Physical Exercise Programs in Older Adults: A Systematic Review and Meta-Analysis.Clocks & sleep · 2023Review
- Effects of Work Stress andInternational journal of environmental research and public health · 2022Article
- Article
- The Association Between Gait Speed and Sleep Problems Among Chinese Adults Aged 50 and Greater.Frontiers in neuroscience · 2022Article
- A Cross-Sectional Study on the Relationship Among Cytokines, 5-HT2A Receptor Polymorphisms, and Sleep Quality of Non-manual Workers in Xinjiang, China.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrently disrupted sleep is a widespread phenomenon in our society. This is worrisome as chronically impaired sleep increases the risk of numerous diseases that place a heavy burden on health services worldwide, including type 2 diabetes, obesity, depression, cardiovascular disease, and dementia. Therefore, strategies mitigating the current societal sleep crisis are needed. SCOPE OF REVIEW: Observational and interventional studies have found that regular moderate to intensive exercise is associated with better subjective and objective sleep in humans, with and without pre-existing sleep disturbances. Here, we summarize recent findings from clinical studies in humans and animal experiments suggesting that molecules that are expressed, produced, and released by the skeletal muscle in response to exercise may contribute to the sleep-improving effects of exercise. MAJOR
conclusionsExercise-induced skeletal muscle recruitment increases blood concentrations of signaling molecules, such as the myokine brain-derived neurotrophic factor (BDNF), which has been shown to increase the depth of sleep in animals. As reviewed herein, BDNF and other muscle-induced factors are likely to contribute to the sleep-promoting effects of exercise. Despite progress in the field, however, several fundamental questions remain. For example, one central question concerns the optimal time window for exercise to promote sleep. It is also unknown whether the production of muscle-induced peripheral factors promoting sleep is altered by acute and chronic sleep disturbances, which has become increasingly common in the modern 24/7 lifestyle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.