Evidence map›Paper›PMID 33045380›Full record

ArticleJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus2020

Slow progressive perifoveal vascular formation in an infant with aggressive posterior retinopathy of prematurity.

Xi Chen, Ryan Imperio, Kai R Seely, Christian Viehland, Joseph A Izatt, S Grace Prakalapakorn, Sharon F Freedman, Cynthia A Toth

2 registry-linked trialsOpen access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02887157 completednot on this map

Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care (BabySTEPS)

TypeobservationalSponsorDuke UniversityRan2016 to 2021Enrolled191ConditionsRetinopathy of Prematurity, Neurodevelopmental Disorders, Macular EdemaArmsSwept Source OCT, Magnetic Resonance Imaging, Scavenged blood collection
NCT04995341 narecruitingnot on this mapstarted 2021, after this paper: background citation

Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care 2 and School Age Follow on Study (BabySTEPS2)

TypeinterventionalSponsorDuke UniversityRan2021 to 2027Enrolled236ConditionsRetinopathy of PrematurityArmsInvestigational ultracompact OCT and OCTA system, retinal photographs
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Insights into the developing fovea revealed by imaging.Progress in retinal and eye research · 2022
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xi ChenDepartment of Ophthalmology, Duke University, Durham, North Carolina. Electronic address: xi2.chen@duke.edu.
Ryan ImperioDepartment of Ophthalmology, Duke University, Durham, North Carolina.
Kai R SeelyDepartment of Ophthalmology, Duke University, Durham, North Carolina.
Christian ViehlandDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.
Joseph A IzattDepartment of Ophthalmology, Duke University, Durham, North Carolina; Department of Biomedical Engineering, Duke University, Durham, North Carolina.
S Grace PrakalapakornDepartment of Ophthalmology, Duke University, Durham, North Carolina.
Sharon F FreedmanDepartment of Ophthalmology, Duke University, Durham, North Carolina.
Cynthia A TothDepartment of Ophthalmology, Duke University, Durham, North Carolina; Department of Biomedical Engineering, Duke University, Durham, North Carolina.
Duke University · US

Funding

Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve CareR01EY025009 · NEI · DUKE UNIVERSITY · PI Xi Chen, CYNTHIA ANN TOTH · 2016 to 2026
$6.6M
NRSA Training CoreTL1TR002555 · NCATS · DUKE UNIVERSITY · PI EDELMAN, DAVID · 2018 to 2022
$3.7M
Retinal Neurovascular Patterning in Preterm InfantsK23EY028227 · NEI · DUKE UNIVERSITY · PI CHEN, XI · 2017 to 2021
$929k
NCATS NIH HHS TL1 TR002555NEI NIH HHS K23 EY028227NEI NIH HHS R01 EY025009
6 · The paper itself

Abstract

Aggressive posterior retinopathy of prematurity (AP-ROP) is a severe form of ROP occurring in preterm infants that is characterized by rapid progression and prominent vascularity. We report the use of investigational bedside noninvasive optical coherence tomography angiography to visualize the slow and progressive perifoveal vascular formation in an infant with AP-ROP treated with bevacizumab. We also document extensive vascular shunts and morphological differences between arrested and growing retinal capillaries at the vascular wavefront.

Indexed as

Retinopathy of PrematurityAngiogenesis InhibitorsBevacizumabGestational AgeHumansInfantInfant, NewbornInfant, PrematureIntravitreal InjectionsLaser CoagulationAngiogenesis InhibitorsBevacizumab

Identifiers

PMID33045380
PMCPMC7749017
OpenAlexW3092260315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.