ArticlePhysiology & behavior2021
Interactions of the estrous cycle, novelty, and light on female and male rat open field locomotor and anxiety-related behaviors.
Article in Physiology & behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization.Frontiers in molecular neuroscience · 2022Pooled it
- Welfare Assessment of Female BALB/c Mice Housed with Different Environmental Enrichment Materials.Animals : an open access journal from MDPI · 2026Article
- Effects of Exercise Type and Sertraline on Anxiety and Social Behavior in a Female Rat Model of PTSD.Brain and behavior · 2026Article
- Functional behavioral profiling of multiple Cre-driver rat lines.Experimental animals · 2026Article
- A Novel Polymorphic Form of Sodium Benzoate (Ω-NaBen): Improved Solubility, Stability, Central Nervous System Effects, and Antipsychotic Activities via D-Amino Acid Regulation.CNS & neurological disorders drug targets · 2026Article
- Sex differences in cardiac graft recovery and pathophysiologic changes in a rat model of donation after circulatory death.Scientific reports · 2025Article
- Acute nicotine vapor attenuates sensorimotor gating deficits in HIV-1 transgenic rats.Psychopharmacology · 2025Article
- Oleoylethanolamide restores stress-induced prepulse inhibition deficits and modulates inflammatory signaling in a sex-dependent manner.Psychopharmacology · 2025Article
- Locomotor Response to Novelty: What Does It Tell Us?Developmental psychobiology · 2025Article
- Sex differences in spontaneous behavior and cognition in mice using an automated behavior monitoring system.Physiology & behavior · 2024Article
- Acute nicotine vapor normalizes sensorimotor gating and reduces locomotor activity deficits in HIV-1 transgenic rats.bioRxiv : the preprint server for biology · 2024Article
- Sleep- and sleep deprivation-related changes of vertex auditory evoked potentials during the estrus cycle in female rats.Scientific reports · 2024Article
- Tactile stimulation of young WAG/Rij rats prevents development of depression but not absence epilepsy.Frontiers in behavioral neuroscience · 2024Article
- The mixed legacy of the rat estrous cycle.Biology of sex differences · 2023Article
- Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice.Neurobiology of stress · 2023Article
- No detectable changes in anxiety-related and locomotor behaviors in adult ovariectomized female rats exposed to estradiol, the ERβ agonist DPN or the ERα agonist PPT.Hormones and behavior · 2023Review
- The impact of the ovarian cycle on anxiety, allopregnanolone, and corticotropin releasing hormone changes after motherhood in female rats and women.Translational psychiatry · 2023Article
- Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats' choroid plexus.Scientific reports · 2023Article
- Mouse spontaneous behavior reflects individual variation rather than estrous state.Current biology : CB · 2023Article
- Social factors influence solo and rat dyads exploration of an unfamiliar open field.Animal cognition · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Animal behavior can be modulated by multiple interacting factors. In rodents such as rats, these factors include, among others, the female estrous cycle, exposure to a novel environment, and light. Here, we used the open field test to disassociate differences in behavior resulting from each of these factors by testing the hypothesis that locomotor and anxiety-related behaviors differ between estrous cycle phases in female rats and that novelty and light exposure concurrently influence these behaviors in both female and male rats. Adult female rats were tested twice under red or white light in estrus and diestrus estrous cycle phases. Adult male rats were also tested twice under either red or white light. In females, an interaction between novelty and estrous cycle phase influenced locomotor and anxiety-related behaviors. In males, novelty influenced locomotor and anxiety-related behaviors differentially under red and white light. Light exposure increased anxiety-related behaviors in both males and females, but reduced locomotor behavior only in females. These findings reveal the complexities of behavioral testing and highlight the importance of factors such as the estrous cycle, novelty, and light exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.