ArticleThe Journal of pediatrics2021
Antibiotic Choice and Clinical Outcomes in Ambulatory Children with Community-Acquired Pneumonia.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Treatment of mild to moderate community-acquired pneumonia in previously healthy children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG-SIMG).Italian journal of pediatrics · 2024Pooled it
- Global Antimicrobial Non-Susceptibility Patterns ofInfection and drug resistance · 2026Review
- Outpatient Antibiotic Use and Treatment Failure Among Children With Pneumonia.JAMA network open · 2024Article
- Cost of Pediatric Pneumonia Episodes With or Without Chest Radiography.Hospital pediatrics · 2024Article
- Quality of antibiotic prescribing for pediatric community-acquired Pneumonia in outpatient care.BMC pediatrics · 2023Article
- Use of antibiotics contrary to guidelines for children's lower respiratory tract infections in different health care settings.European journal of pediatrics · 2023Article
- Association of Chest Radiography With Outcomes in Pediatric Pneumonia: A Population-Based Study.Hospital pediatrics · 2023Article
- Regional Perspective of Antimicrobial Stewardship Programs in Latin American Pediatric Emergency Departments.Antibiotics (Basel, Switzerland) · 2023Review
- Trends inOpen forum infectious diseases · 2023Article
- Antibiotic use and outcomes among children hospitalized with suspected pneumonia.Journal of hospital medicine · 2022Article
- Variation in bacterial pneumonia diagnoses and outcomes among children hospitalized with lower respiratory tract infections.Journal of hospital medicine · 2022Article
- Antibiotic use in children before, during and after hospitalisation.Pharmacoepidemiology and drug safety · 2022Article
- Association Between Procalcitonin and Antibiotics in Children With Community-Acquired Pneumonia.Hospital pediatrics · 2022Article
- Macrolides (alone or in combination) should be used as first-line empirical therapy of community-acquired pneumonia in children: myth or maxim?Breathe (Sheffield, England) · 2021Article
- Assessment of nasopharyngeal Streptococcus pneumoniae colonization does not permit discrimination between Canadian children with viral and bacterial respiratory infection: a matched-cohort cross-sectional study.BMC infectious diseases · 2021Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
objectivesTo describe antibiotic prescribing patterns in ambulatory children with community-acquired pneumonia and to assess the relationship between antibiotic selection and clinical outcomes. STUDY
designThis was a retrospective cohort study of ambulatory Medicaid-enrolled children 0-18 years of age diagnosed with community-acquired pneumonia from 2010 to 2016. The exposure was antibiotic class: narrow-spectrum (aminopenicillins), broad-spectrum (amoxicillin/clavulanate and cephalosporins), macrolide monotherapy, macrolides with narrow-spectrum antibiotics, or macrolides with broad-spectrum antibiotics. The associations between antibiotic selection and the outcomes of subsequent hospitalization and development of severe pneumonia (chest drainage procedure, intensive care admission, mechanical ventilation) were assessed, controlling for measures of illness severity.
resultsAmong 252 177 outpatient pneumonia visits, macrolide monotherapy was used in 43.2%, narrow-spectrum antibiotics in 26.1%, and broad-spectrum antibiotics in 24.7%. A total of 1488 children (0.59%) were subsequently hospitalized and 117 (0.05%) developed severe pneumonia. Compared with children receiving narrow-spectrum antibiotics, the odds of subsequent hospitalization were higher in children receiving broad-spectrum antibiotics (aOR, 1.34; 95% CI, 1.17-1.52) and lower in children receiving macrolide monotherapy (aOR, 0.64; 95% CI, 0.55-0.73) and macrolides with narrow-spectrum antibiotics (aOR, 0.62; 95% CI, 0.39-0.97). Children receiving macrolide monotherapy had lower odds of developing severe pneumonia than children receiving narrow-spectrum antibiotics (aOR, 0.56; 95% CI, 0.33-0.93). However, the absolute risk difference was <0.5% for all analyses.
conclusionsMacrolides are the most commonly prescribed antibiotic for ambulatory children with community-acquired pneumonia. Subsequent hospitalization and severe pneumonia are rare. Future efforts should focus on reducing broad-spectrum and macrolide antibiotic prescribing.
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