Evidence map›Paper›PMID 33045133›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2020

Standardized treatment to improve hypertension control in primary health care: The HEARTS in the Americas Initiative.

Donald J DiPette, Kenneth Goughnour, Eric Zuniga, Jamario Skeete, Emily Ridley, Sonia Angell, Jeffrey Brettler, Norm R C Campbell, Antionio Coca, Kenneth Connell and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 56 citations in OpenAlex.

  1. Observational
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  5. Article
  6. [HEARTS best practices in the Dominican RepublicBoas práticas da iniciativa HEARTS na República Dominicana].Revista panamericana de salud publica = Pan American journal of public health · 2026
    Article
  7. Article
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  13. Review
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  15. Hypertension control applying the HEARTS in the Americas protocol in Trinidad: A cross-sectional study.Revista panamericana de salud publica = Pan American journal of public health · 2025
    Article
  16. Article
  17. Review
  18. The Rationale for Using Fixed-Dose Combination Therapy in the Management of Hypertension in Colombia: A Narrative Review.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 18 institutions in 12 countries.

Donald J DiPetteSchool of Medicine, University of South Carolina, Columbia, SC, USA.ORCID 0000-0002-5762-9104
Kenneth GoughnourWomen Influencing Health, Education and Rule of Law (WI-HER), Vienna, VA, USA.
Eric ZunigaHealth Service of Antofagasta, University of Antofagasta, Antofagasta, Chile.
Jamario SkeeteDepartment of Internal Medicine, Division of Cardiology, Rush University Medical Center, Chicago, IL, USA.
Emily RidleyPrisma Health, Columbia, SC, USA.ORCID 0000-0002-5043-1920
Sonia AngellCalifornia Department of Public Health, California, IL, USA.
Jeffrey BrettlerKaiser Permanente Southern California, California, IL, USA.
Norm R C CampbellDepartment of Medicine, Physiology and Pharmacology and Community Health Sciences, O'Brien Institute for Public Health and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-1093-4742
Antionio CocaDepartment of Internal Medicine, Hypertension and Vascular Risk Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Kenneth ConnellFaculty of Medical Sciences, The University of the West Indies, St Michael, Barbados.
Rohit DoonMinistry of Health, Port of Spain, Trinidad and Tobago.
Marc JaffeDivision of Endocrinology, Kaiser Permanente, San Francisco, CA, USA.
Patricio Lopez-JaramilloMASIRA Research Institute, Santander University (UDES), Bucaramanga, Colombia.
Andrew MoranResolve to Save Lives, An initiative of Vital Strategies, New York, NY, USA.
Marcelo OriasSanatorio Allende Córdoba, Universidad Nacional de Córdoba, Cordoba, Argentina.
Daniel J PineiroUniversidad de Buenos Aires, Buenos Aires, Argentina.
Andres RosendeNational Ministry of Health, Buenos Aires, Argentina.
Yamilé Valdés GonzálezNational Technical Advisory Commission on Hypertension, Havana, Cuba.
Pedro OrdunezDepartment of Non-Communicable Diseases and Mental Health, Pan American Health Organization, Washington, DC, USA.ORCID 0000-0002-9871-6845
Kaiser Permanente · USCalifornia Department of Public Health · USColumbia University Irving Medical Center · USHospital Clínic de Barcelona · ESHospital Oncológico Docente "Conrado Benítez García" · CUMinisterio de Salud · ARPort of Spain General Hospital · TTPrisma Health · USRoyal University of Law and Economics · KHRush University Medical Center · USUniversidad de Antofagasta · CLUniversidad de Buenos Aires · ARUniversidad De Santander · COUniversidad Nacional de Córdoba · ARUniversity of Calgary · CAUniversity of South Carolina · USUniversity of the West Indies · BBWorld Health Organization Regional Office for the Americas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension is the leading risk factor for cardiovascular disease (CVD) worldwide. Despite the availability of effective antihypertensive medications, the control of hypertension at a global level is dismal, and consequently, the CVD burden continues to increase. In response, countries in Latin America and the Caribbean are implementing the HEARTS in the Americas, a community-based program that focuses on increasing hypertension control and CVD secondary prevention through risk factor mitigation. One key pillar is the implementation of a standardized hypertension treatment protocol supported by a small, high-quality formulary. This manuscript describes the methodology used by the HEARTS in the Americas program to implement a population-based standardized hypertension treatment protocol. It is rooted in a seamless transition from existing treatment practices to best practice using pharmacologic protocols built around a core set of ideal antihypertensive medications. In alignment with recent major hypertension guidelines, the HEARTS in the Americas protocols call for the rapid control of blood pressure, through the use of two antihypertensive medications, preferably in the form of a single pill, fixed-dose combination, in the initial treatment of hypertension. To date, the HEARTS in the Americas program has seen the improvement in antihypertensive medication formularies and the establishment of pharmacologic treatment protocols tailored to individual participating countries. This has translated to significant increases in hypertension control rates post-program implementation in these jurisdictions. Thus, the HEARTS in the Americas program could serve as a model, for not only the Americas Region but globally, and ultimately decrease the burden of CVD.

Indexed as

HypertensionAntihypertensive AgentsCaribbean RegionHumansLatin AmericaPrimary Health CareAntihypertensive Agentsfixed-dose combination therapyHEARTS in the Americashypertension controlhypertension formularieshypertension protocols

Identifiers

PMID33045133
PMCPMC8029673
OpenAlexW3091777118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.