ArticleJournal of the American Geriatrics Society2020
COVID-19 in Older Adults: A Series of 76 Patients Aged 85 Years and Older with COVID-19.
Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Are gastrointestinal symptoms associated with higher risk of Mortality in COVID-19 patients? A systematic review and meta-analysis.BMC gastroenterology · 2022Pooled it
- Delirium is a good predictor for poor outcomes from coronavirus disease 2019 (COVID-19) pneumonia: A systematic review, meta-analysis, and meta-regression.Journal of psychiatric research · 2021Pooled it
- Chronic Diseases as a Predictor for Severity and Mortality of COVID-19: A Systematic Review With Cumulative Meta-Analysis.Frontiers in medicine · 2021Pooled it
- B-Type Natriuretic Peptide Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression.Frontiers in cardiovascular medicine · 2021Pooled it
- Mortality Trends in Pre-COVID-19 and COVID-19 Eras Among Oldest Veterans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study.European geriatric medicine · 2024Observational
- Increased levels of GM-CSF and CXCL10 and low CD8Immunity & ageing : I & A · 2024Article
- Association of Inflammatory Mediators with Mitochondrial DNA Variants in Geriatric COVID-19 Patients.Aging and disease · 2024Article
- Susceptibility to acute cognitive dysfunction in aged mice is underpinned by reduced white matter integrity and microgliosis.Communications biology · 2024Article
- Atypical Presentation of COVID-19 in Older Adults: A Scoping Review.Portuguese journal of public health · 2023Article
- Impact of COVID-19 in individuals with and without pre-existent digestive disorders with a particular focus on elderly patients.World journal of gastroenterology · 2023Review
- Atypical presentation of COVID-19 in older patients is associated with frailty but not with adverse outcomes.European geriatric medicine · 2023Article
- Clinical presentation of COVID-19 and association with outcomes among hospitalized older adults.Journal of the American Geriatrics Society · 2023Article
- Older patients with COVID-19 and neuropsychiatric conditions: A study of risk factors for mortality.Brain and behavior · 2022Observational
- COVID-19 in Older Individuals Requiring Hospitalization.Infectious disease reports · 2022Article
- Review
- Geriatric Syndromes in Older Adults Hospitalized with COVID-19 in Montreal, Canada.Canadian geriatrics journal : CGJ · 2022Article
- Beta receptor blocker therapy for the elderly in the COVID-19 era.World journal of clinical cases · 2022Review
- In-hospital mortality prediction using frailty scale and severity score in elderly patients with severe COVID-19.Acute and critical care · 2022Article
- Choices and Outcomes of the Oldest Old Admitted During the First Wave of COVID-19 in New York City.Journal of palliative care · 2022Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical presentation and risk factors of death in COVID-19 in oldest adults have not been well characterized.
objectivesTo describe clinical features and outcome of COVID-19 in patients older than 85 years and study risk factors for mortality.
designProspective cohort. PARTICIPANTS AND
settingPatients aged 85 years and older, admitted in noncritical care units at the University Hospital Lariboisière Fernand-Widal (Paris, France) for confirmed severe acute respiratory syndrome coronavirus 2 infection were included and followed up for 21 days. MEASUREMENTS: Clinical and laboratory findings were collected. Cox survival analysis was performed to explore factors associated with death.
resultsFrom March 14 to April 11, 2020, 76 patients (median age = 90 (86-92) years; women = 55.3%) were admitted for confirmed COVID-19. Of the patients, 64.5% presented with three or more comorbidities. Most common symptoms were asthenia (76.3%), fever (75.0%) and confusion and delirium (71.1%). An initial fall was reported in 25.0% of cases, and digestive symptoms were reported in 22.4% of cases. COVID-19 was severe in 51.3% of cases, moderate in 32.9%, and mild in 15.8%. Complications included acute respiratory syndrome (28.9%), cardiac decompensation (14.5%), and hypotensive shock (9.0%). Fatality at 21 days was 28.9%, after a median course of disease of 13 (8-17) days. Males were overrepresented in nonsurvivors (68.2%). In survivors, median length of stay was 12 (9-19.5) days. Independent predictive factors of death were C-reactive protein level at admission and lymphocyte count at nadir.
conclusionSpecific clinical features, multiorgan injury, and high case fatality rate are observed in older adults with COVID-19. However, rapid diagnosis, appropriate care, and monitoring seem to improve prognosis.
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