Evidence map›Paper›PMID 33045022›Full record

SynthesisPloS one2020

Dexmedetomidine use in pediatric strabismus surgery: A systematic review and meta-analysis.

Fu-Wei Chiang, Jin-Lin Chang, Shih-Chang Hsu, Kuo-Yuan Hsu, Karen Chia-Wen Chu, Chun-Jen Huang, Chyi-Huey Bai, Chiehfeng Chen, Chin-Wang Hsu, Yuan-Pin Hsu

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07523438 (Effect of Two Different Doses of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery , A Randomized Clinical Trial), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07523438 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Two Different Doses of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery , A Randomized Clinical Trial

TypeinterventionalSponsorAlexandria UniversityRan2026 to 2026Enrolled120ConditionsDexmedetomidine, Emergence AgitationArmshigh dex group, low dex group
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fu-Wei ChiangEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Jin-Lin ChangEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Shih-Chang HsuEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0003-1010-1182
Kuo-Yuan HsuEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Karen Chia-Wen ChuEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Chun-Jen HuangDepartment of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Chyi-Huey BaiDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chiehfeng ChenEvidence-Based Medicine Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Chin-Wang HsuEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Yuan-Pin HsuEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0001-8895-9133
Wan Fang Hospital · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCommon complications of pediatric strabismus surgery, including emergence agitation (EA), postoperative nausea and vomiting (PONV), and postoperative pain, may be prevented using dexmedetomidine, which is an anxiolytic and analgesic. This systematic review and meta-analysis assessed the effects of dexmedetomidine in patients who had undergone pediatric strabismus surgery.

methodFive databases were searched for randomized controlled trials published from database inception to April 2020 that compared dexmedetomidine use with placebo or active comparator use and evaluated EA, PONV, or postoperative pain incidence (main outcomes) in patients who had undergone pediatric strabismus surgery. Oculocardiac reflex (OCR) incidence and postanesthesia care unit (PACU) stay duration were considered as safety outcomes. All meta-analyses were performed using a random-effects model.

resultsIn the nine studies meeting our inclusion criteria, compared with placebo use, dexmedetomidine use reduced EA incidence [risk ratio (RR): 0.39; 95% confidence interval (CI): 0.25-0.62, I2 = 66%], severe EA incidence (RR: 0.27, 95% CI: 0.17-0.43, I2 = 0%), PONV incidence (RR: 0.33, 95% CI: 0.21-0.54, I2 = 0%), analgesia requirement (RR: 0.38, 95% CI: 0.25-0.57, I2 = 0%), and pain scores (standardized mean difference: -1.02, 95% CI: -1.44 to -0.61, I2 = 75%). Dexmedetomidine also led to lower EA incidence in the sevoflurane group than in the desflurane group (RR: 0.26 for sevoflurane vs. 0.45 for desflurane). Continuous dexmedetomidine infusion (RR: 0.19) led to better EA incidence reduction than did bolus dexmedetomidine infusion at the end of surgery (RR: 0.26) or during the peri-induction period (RR: 0.36). Compared with placebo use, dexmedetomidine use reduced OCR incidence (RR: 0.63; I2 = 40%). No significant between-group differences were noted for PACU stay duration.

conclusionIn patients who have undergone pediatric strabismus surgery, dexmedetomidine use may alleviate EA, PONV, and postoperative pain and reduce OCR incidence. Moreover, dexmedetomidine use does not affect the PACU stay duration.

Indexed as

Analgesics, Non-NarcoticAnesthesia Recovery PeriodChildChild, PreschoolDexmedetomidineFemaleHumansHypnotics and SedativesInfantMalePostoperative ComplicationsRandomized Controlled Trials as TopicReflex, OculocardiacStrabismusAnalgesics, Non-NarcoticDexmedetomidineHypnotics and Sedatives

Identifiers

PMID33045022
PMCPMC7549777
OpenAlexW3092555050

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.