SynthesisPLoS genetics2020
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 8 pooled it
19.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 8 syntheses or guidelines pooled it, 226 citations in OpenAlex.
- Gene-environment interplay explaining individual variation in BMI outcomes: a systematic review and meta-analysis of studies using polygenic indices.International journal of obesity (2005) · 2026Pooled it
- Identifying Key Predictors of Mid-Childhood Obesity in a Population-Based Cohort Study: An Evidence Synthesis and Predictive Modeling Study.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry.Nature human behaviour · 2025Pooled it
- Application of Mendelian randomized research method in oncology research: bibliometric analysis.Frontiers in oncology · 2024Pooled it
- The Genetic Basis of Childhood Obesity: A Systematic Review.Nutrients · 2023Pooled it
- Phenotypic and Genetic Links between Body Fat Measurements and Primary Open-Angle Glaucoma.International journal of molecular sciences · 2023Pooled it
- Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis.BMC medicine · 2022Pooled it
- Genome-wide mapping of common and rare variant effects on adiposity across childhood.Nature genetics · 2026Article
- Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study.International journal of epidemiology · 2026Article
- Examining the role of insulin-like growth factor 1 in the pathophysiology of carpal tunnel syndrome: a Mendelian randomization study.International journal of epidemiology · 2026Article
- Genetic and environmental influences on educational disparities in adult weight change: an individual-based pooled analysis of 11 twin cohorts.International journal of obesity (2005) · 2026Article
- Causal effects of life-course obesity on sleep apnoea: a Mendelian randomization study.Internal and emergency medicine · 2026Article
- Genetic risk for high body mass index before and amidst the obesity epidemic: Cross-cohort analysis of four british birth cohort studies.PLoS genetics · 2026Article
- Parental body mass index and offspring childhood body size and eating behaviour: A structural equation modelling analysis in the Norwegian Mother, Father and Child Cohort Study.PLoS medicine · 2026Article
- Body mass index, physical activity, and epigenetic aging: a cross-population study.Clinical epigenetics · 2026Observational
- Management of Childhood Obesity.International journal of molecular sciences · 2026Review
- Article
- Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank.PLoS genetics · 2026Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
146 authors at 20 institutions in 18 countries.
Suzanne VogelezangThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Jonathan P BradfieldQuantinuum Research LLC, San Diego, California, United States of America.
Tarunveer S AhluwaliaCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
John A CurtinDivision of Infection Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Timo A LakkaInstitute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Claire MonnereauThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Evie StergiakouliMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.
Anni HeiskalaCenter for Life Course Health Research, University of Oulu, Oulu, Finland.
Momoko HorikoshiWellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Iryna O FedkoDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Natalia Vilor-TejedorISGlobal, Barcelona, Spain.
Diana L CousminerDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Marie StandlInstitute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.
Carol A WangSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, Australia.
Jorma ViikariDepartment of Medicine, University of Turku, Turku, Finland.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Carmen ÍñiguezCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Niina PitkänenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Alessandra ChesiDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Jonas BacelisDepartment of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg Sweden.
Loic YengoUniversity Lille, Centre National de la Recherche Scientifique, Institut Pasteur de Lille, UMR 8199-European Genomic Institute for Diabetes, Lille, France.
Maties TorrentArea de Salut de Menorca ib-salut, Menorca, Spain.
Ioanna NtallaWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Øyvind HelgelandKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Saskia SelzamSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Judith M VonkDepartment of Epidemiology, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Mohammed H ZafarmandDepartment of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Barbara HeudeUniversité de Paris, CRESS, INSERM, INRA, Paris, France.
Ismaa Sadaf FarooqiUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
Akram AlyassDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
Robin N BeaumontInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, United Kingdom.
Christian T HaveNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Peter RzehakDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilians Universität München (LMU), Munich, Germany.
Jose Ramon BilbaoUniversity of the Basque Country (UPV/EHU), Leioa, Spain.
Theresia M SchnurrNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Inês BarrosoWellcome Sanger Institute, Cambridge, United Kingdom.
Klaus BønnelykkeCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Lawrence J BeilinMedical School, The University of Western Australia, Perth, Western Australia, Australia.
Lisbeth CarstensenDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Marie-Aline CharlesUniversité de Paris, CRESS, INSERM, INRA, Paris, France.
Bo ChawesCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Karine ClémentNutrition and Obesities; systemic approaches research unit, Sorbonne University, INSERM, Pitie- Salpêtrière Hospital, Assistance Publique hôpital de Paris, Paris, France.
Ricardo Closa-MonasteroloPediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili, IISPV, Reus, Spain.
Adnan CustovicNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Joaquin EscribanoPediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili, IISPV, Reus, Spain.
Maria Groen-BlokhuisDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Veit GroteDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilians Universität München (LMU), Munich, Germany.
Dariusz GruszfeldNeonatal Department, Children's Memorial Health Institute, Warsaw, Poland.
Hakon HakonarsonCenter for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Andrew T HattersleyInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, United Kingdom.
Mette HollenstedNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jouke-Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Elina HyppönenAustralian Centre for Precision Health, University of South Australia Cancer Research Institute, Adelaide, Australia.
Stefan JohanssonKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Raimo JoroInstitute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Ville KarhunenDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom.
Wieland KiessCenter for Pediatric Research, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Bridget A KnightNIHR Exeter Clinical Research Facility, College of Medicine and Health, University of Exeter, and Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom.
Berthold KoletzkoDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilians Universität München (LMU), Munich, Germany.
Andreas KühnapfelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Kathrin LandgrafCenter for Pediatric Research, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Jean-Paul LanghendriesCHC-Health Group, Liège, Belgium.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Jaakko T LeinonenInstitute For Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.
Aihuali LiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
Virpi LindiUniversity of Eastern Finland Library Kuopio, Kuopio, Finland.
Estelle LowryCenter for Life Course Health Research, University of Oulu, Oulu, Finland.
Mariona BustamanteISGlobal, Barcelona, Spain.
Carolina Medina-GomezThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Kim F MichaelsenDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Camilla S MorgenDepartment of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark.
Trevor A MoriMedical School, The University of Western Australia, Perth, Western Australia, Australia.
Tenna R H NielsenDepartment of Pediatrics, Hvidovre Hospital, Hvidovre, Denmark.
Harri NiinikoskiDepartment of Physiology, University of Turku, Turku, Finland.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center, Groningen, the Netherlands.
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Kalliope PanoutsopoulouWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Craig E PennellSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, Australia.
Christine PowerPopulation, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Sijmen A ReijneveldDepartment of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Angela SimpsonDivision of Infection Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Peter D SlyChild Health Research Centre, University of Queensland, Brisbane, Australia.
Jakob StokholmCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Kook K TeoDepartment of Medicine, McMaster University, Hamilton, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
Elisabeth ThieringInstitute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.
Nicholas J TimpsonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Catharina E M van BeijsterveldtDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Barbera D C van SchaikBioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Marc VaudelKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Elvira VerduciDepartment of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy.
Rebecca K VindingCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Mandy VogelCenter for Pediatric Research, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Eleftheria ZegginiWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Sylvain SebertCenter for Life Course Health Research, University of Oulu, Oulu, Finland.
Mads V LindDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Christopher D BrownDepartment of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Loreto Santa-MarinaConsortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiologia y Salud Publica-CIBERESP), Barcelona, Spain.
Eva ReischlResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum Muenchen, Munich, Germany.
Christine Frithioff-BøjsøeNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
David MeyreDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
Eleanor WheelerWellcome Sanger Institute, Cambridge, United Kingdom.
Ken OngMedical Research Council Epidemiology Unit & Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.
Ellen A NohrResearch Unit for Gynaecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Tanja G M VrijkotteDepartment of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Gerard H KoppelmanUniversity Medical Center Groningen, University of Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC (Groningen Research Institute for Asthma and COPD), Groningen, the Netherlands.
Robert PlominSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Pål R NjølstadKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
George D DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Philippe FroguelUniversity Lille, Centre National de la Recherche Scientifique, Institut Pasteur de Lille, UMR 8199-European Genomic Institute for Diabetes, Lille, France.
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bo JacobssonDepartment of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg Sweden.
Rachel M FreathyInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, United Kingdom.
Babette S ZemelDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Martine VrijheidISGlobal, Barcelona, Spain.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Holger KirstenInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Patrick G HoltTelethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
Joachim HeinrichInstitute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.
Elisabeth WidénInstitute For Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.
Jordi SunyerISGlobal, Barcelona, Spain.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Marjo-Riitta JärvelinCenter for Life Course Health Research, University of Oulu, Oulu, Finland.
Antje KörnerCenter for Pediatric Research, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
George Davey SmithMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.
Jens-Christian HolmNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mustafa AtalayInstitute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
Clare MurrayDivision of Infection Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Hans BisgaardCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Mark I McCarthyWellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Early Growth Genetics Consortium
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Struan F A GrantCenter for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-9801-5774
University of Copenhagen · DKErasmus MC · NLChildren's Hospital of Philadelphia · USUniversity Medical Center Groningen · NLUniversity of Turku · FIVrije Universiteit Amsterdam · NLImpact · CAStatens Serum Institut · DKUniversity of Cambridge · GBUniversity of Eastern Finland · FIUniversity of Exeter · GBHelmholtz Zentrum München · DEIFB Adiposity Diseases · DEInserm · FRLeipzig University · DELudwig-Maximilians-Universität München · DEManchester Academic Health Science Centre · GBUniversitat Pompeu Fabra · ESUniversity of Helsinki · FICentre for Human Genetics · GB
Funding
Genome Wide Association Study of Bone Mineral Accretion During ChildhoodR01HD058886 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A, ZEMEL, BABETTE S · 2010 to 2013
$3.1MIntegrating genome-scale data to reveal causal mechanisms in type 2 diabetesU01DK105535 · NIDDK · UNIVERSITY OF OXFORD · PI GLOYN, ANNA LOUISE · 2015 to 2019
$1.7MDepartment of Health NF-SI-0617-10090Medical Research Council G0601361Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00006/2Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/3Medical Research Council MC_UU_12012/5Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MRC_MC_UU_12012/5Medical Research Council MR/K002449/1Medical Research Council MR/K002449/2Medical Research Council MR/S025340/1Medical Research Council MR/T014067/1NICHD NIH HHS R01 HD058886NIDDK NIH HHS U01 DK105535Wellcome Trust 090532Wellcome Trust 098381Wellcome Trust 098395/Z/12/ZWellcome Trust 098497/Z/12/ZWellcome Trust 106130Wellcome Trust 202802/Z/16/ZWellcome Trust 203141Wellcome Trust 212259Wellcome Trust WT104150Wellcome Trust WT206194
Abstract
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
Indexed as
Genetic Predisposition to DiseaseAdolescentAdultBlood PressureBody Mass IndexCardiometabolic Risk FactorsCardiovascular DiseasesChildChild, PreschoolDiabetes Mellitus, Type 2FemaleGenome-Wide Association StudyHumansMaleMenarcheMendelian Randomization AnalysisMonosaccharide Transport ProteinsNedd4L protein, humanNedd4 Ubiquitin Protein LigasesSLC45a3 protein, human
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