ArticlePLoS neglected tropical diseases2020
Differential pathogenesis of Usutu virus isolates in mice.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 28 citations in OpenAlex.
- A versatile fluorescent reporter for Usutu virus drug screening and infection tracking.PNAS nexus · 2026Article
- Susceptibility of wild and domestic songbirds to Usutu virus.PLoS neglected tropical diseases · 2026Article
- North American Culex pipiens mosquitoes are competent for Usutu virus transmission.Npj viruses · 2026Article
- Article
- Article
- Cross-protection against St. Louis encephalitis virus and Usutu virus by West Nile virus convalescent plasma.Virology · 2025Article
- STAT1-mediated interferon signaling in the hematopoietic system is essential for restricting Usutu virus infection in vivo.PLoS neglected tropical diseases · 2025Article
- Attenuating Mutations in Usutu Virus: Towards Understanding Orthoflavivirus Virulence Determinants and Live Attenuated Vaccine Design.Vaccines · 2025Article
- Cross-Protection between West Nile Virus and Emerging Flaviviruses in Wild Birds.The American journal of tropical medicine and hygiene · 2025Article
- Dose and strain dependent lethality of Usutu virus in an IfnarNpj viruses · 2025Article
- Recombinant chimeric horsepox virus (TNX-801) is attenuated relative to vaccinia virus strains in bothmSphere · 2024Article
- Emerging mosquito-borne flaviviruses.mBio · 2024Review
- Virulence and transmission vary between Usutu virus lineages in Culex pipiens.PLoS neglected tropical diseases · 2024Article
- Review
- Epidemiology, surveillance and diagnosis of Usutu virus infection in the EU/EEA, 2012 to 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Review
- Longitudinal Study of the Occurrence of Usutu Virus and West Nile Virus Infections in Birds in a Zoological Garden in Northern Germany.Pathogens (Basel, Switzerland) · 2023Article
- Experimental infections in red-legged partridges reveal differences in host competence between West Nile and Usutu virus strains from Southern Spain.Frontiers in cellular and infection microbiology · 2023Article
- Competition between two Usutu virus isolates in cell culture and in the common house mosquitoFrontiers in microbiology · 2023Article
- Article
- First Human Usutu Virus Reported in Asti (Piedmont, Italy, August 2022) and Early Follow-Up.Tropical medicine and infectious disease · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Usutu virus (USUV; Flavivirus), a close phylogenetic and ecological relative of West Nile virus, is a zoonotic virus that can cause neuroinvasive disease in humans. USUV is maintained in an enzootic cycle between Culex mosquitoes and birds. Since the first isolation in 1959 in South Africa, USUV has spread throughout Africa and Europe. Reported human cases have increased over the last few decades, primarily in Europe, with symptoms ranging from mild febrile illness to severe neurological effects. In this study, we investigated whether USUV has become more pathogenic during emergence in Europe. Interferon α/β receptor knockout (Ifnar1-/-) mice were inoculated with recent USUV isolates from Africa and Europe, as well as the historic 1959 South African strain. The three tested African strains and one European strain from Spain caused 100% mortality in inoculated mice, with similar survival times and histopathology in tissues. Unexpectedly, a European strain from the Netherlands caused only 12% mortality and significantly less histopathology in tissues from mice compared to mice inoculated with the other strains. Viremia was highest in mice inoculated with the recent African strains and lowest in mice inoculated with the Netherlands strain. Based on phylogenetics, the USUV isolates from Spain and the Netherlands were derived from separate introductions into Europe, suggesting that disease outcomes may differ for USUV strains circulating in Europe. These results also suggest that while more human USUV disease cases have been reported in Europe recently, circulating African USUV strains are still a potential major health concern.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.