Evidence map›Paper›PMID 33044912›Full record

ArticleRNA biology2021

SID-2 negatively regulates development likely independent of nutritional dsRNA uptake.

Fabian Braukmann, David Jordan, Benjamin Jenkins, Albert Koulman, Eric Alexander Miska

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fabian BraukmannWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2660-450X
David JordanWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
Benjamin JenkinsCore Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Albert KoulmanCore Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9998-051X
Eric Alexander MiskaWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4450-576X
University of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M027252/1Cancer Research UK 11832Cancer Research UK 18583Cancer Research UK 27826Medical Research Council MC_UU_00014/5Wellcome TrustWellcome Trust 092096/Z/10/ZWellcome Trust 104640/Z/14/Z
6 · The paper itself

Abstract

RNA interference (RNAi) is a gene regulatory mechanism based on RNA-RNA interaction conserved through eukaryotes. Surprisingly, many animals can take-up human-made double stranded RNA (dsRNA) from the environment to initiate RNAi suggesting a mechanism for dsRNA-based information exchange between organisms and their environment. However, no naturally occurring example has been identified since the discovery of the phenomenon 22 years ago. Therefore it remains enigmatic why animals are able to take up dsRNA. Here, we explore other possible functions by performing phenotypic studies of dsRNA uptake deficient

Indexed as

Gene Expression Regulation, DevelopmentalRNA InterferenceAnimalsAnimals, Genetically ModifiedBiological TransportCaenorhabditis elegansCaenorhabditis elegans ProteinsEmbryo, NonmammalianGene Expression ProfilingHumansLarvaLipid MetabolismMembrane ProteinsMutationRNA, Double-StrandedCaenorhabditis elegans ProteinsMembrane ProteinsRNA, Double-StrandedSID-2 protein, C elegansdouble stranded RNAEnvironmental RNAinutritionRNA communicationRNAi

Identifiers

PMID33044912
PMCPMC8081039
OpenAlexW3092568917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.