Evidence map›Paper›PMID 33044802›Full record

SynthesisHuman brain mapping2022

Greater male than female variability in regional brain structure across the lifespan.

Lara M Wierenga, Gaelle E Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn I Alpert, Ole A Andreassen and 150 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 4 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Converging evidence for greater male variability in time, risk, and social preferences.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Pooled it
  4. Sex Differences in Episodic Memory Variance.Frontiers in psychology · 2020
    Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The progression of sex differences in brain networks across the lifespan.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
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  15. Review
  16. Article
  17. Article
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  19. Review
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

160 authors at 20 institutions in 17 countries.

Lara M WierengaInstitute of Psychology, Leiden University, Leiden, The Netherlands.ORCID 0000-0001-9362-563X
Gaelle E DoucetDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-4120-0474
Danai DimaDepartment of Psychology, School of Arts and Social Sciences, City, University of London, London, UK.
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Moji AghajaniDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Theophilus N AkudjeduCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Anton Albajes-EizagirreFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Dag AlnaesNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Kathryn I AlpertDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Ole A AndreassenNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Alan AnticevicDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.
Philip AshersonSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
Nuria BargalloImaging Diagnostic Center, Hospital Clínic, Barcelona, Spain.
Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
Ramona Baur-StreubelDepartment for Clinical Psychology, Würzburg University, Margetshöchheim, Germany.
Alessandro BertolinoDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Aurora BonvinoDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Dorret I BoomsmaDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Stefan BorgwardtDepartment of Psychiatry, University of Basel, Basel, Switzerland.
Josiane BourqueDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anouk den BraberDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
Alan BreierDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Rachel M BrouwerDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-7466-1544
Jan K BuitelaarDepartment of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.
Geraldo F BusattoLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Atlanta, Georgia, USA.
Erick J Canales-RodríguezFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Dara M CannonCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Xavier CaserasMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Francisco X CastellanosDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
Tiffany M Chaim-AvanciniLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Christopher Rk ChingImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-2921-3408
Vincent P ClarkPsychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.
Patricia J ConrodCHU Sainte-Justine Research Center, Montreal, Quebec, Canada.
Annette ConzelmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany.
Fabrice CrivelloGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Bordeaux, France.
Christopher G DaveyCentre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Erin W DickieCampbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada.
Stefan EhrlichDivision of Psychological & Social Medicine and Developmental Neurosciences; Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
Dennis Van't EntDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.ORCID 0000-0002-3132-1996
Jean-Paul FoucheDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa.ORCID 0000-0002-0830-2324
Barbara FrankeDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Paola Fuentes-ClaramonteFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Eco Jc de GeusDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Annabella Di GiorgioIRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
David C GlahnTommy Fuss Center for Neuropsychiatric Disease Research, Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4749-6977
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, California, USA.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
Patricia GrunerDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.
Raquel E GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ruben C GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Tiril P GurholtNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-1272-7616
Lieuwe de HaanDepartment of Early Psychosis, Amsterdam UMC, Amsterdam, The Netherlands.
Beathe HaatveitNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ben J HarrisonMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Australia.
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sean N HattonBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Dirk J HeslenfeldDepartments of Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Odile A van den HeuvelDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.ORCID 0000-0002-9804-7653
Ian B HickieBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Pieter J HoekstraDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
Avram J HolmesDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.
Martine HoogmanDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0002-1261-7628
Norbert HostenInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Fleur M HowellsNeuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa.
Hilleke E Hulshoff PolDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-2038-5281
Chaim HuyserDe Bascule, Academic center child and adolescent psychiatry, Duivendrecht, The Netherlands.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Anthony C JamesDepartment of Psychiatry, Warneford Hospital, Oxford, UK.
Jiyang JiangCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Erik G JönssonNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
John A JoskaDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Andrew J KalninDepartment of Radiology, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Karolinska Schizophrenia Project (KaSP) Consortium
Marieke KleinDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Laura KoendersDepartment of Early Psychosis, Amsterdam UMC, Amsterdam, The Netherlands.
Knut K KolskårNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID 0000-0003-3878-814X
Bernd KrämerSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-1145-9103
Jonna KuntsiSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Jim LagopoulosSunshine Coast Mind and Neuroscience Thompson Institute, Birtinya, Queensland, Australia.
Luisa LazaroCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Irina S LebedevaLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
Phil H LeeDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Christine LochnerSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, Western Cape, South Africa.
Marise Wj MachielsenDepartment of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
Sophie MaingaultInstitut des maladies neurodégénératives, Université de Bordeaux, Bordeaux, France.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Ignacio Martínez-ZalacaínDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain.
David Mataix-ColsCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Bernard MazoyerUniversity of Bordeaux, Bordeaux, France.
Brenna C McDonaldDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Colm McDonaldCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Katie L McMahonHerston Imaging Research Facility and School of Clinical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Genevieve McPhilemyCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Dennis van der MeerNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
José M MenchónCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Jilly NaaijenDepartment of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.
Lars NybergDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Jaap OosterlaanEmma Children's Hospital, Amsterdam UMC University of Amsterdam and Vrije Universiteit Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands.
Yannis PaloyelisDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Paul PauliDepartment of Psychology, University of Würzburg, Würzburg, Germany.
Giulio PergolaDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Edith Pomarol-ClotetFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Maria J PortellaCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Joaquim RaduaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfur am Maint, Germany.
Geneviève RichardNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Joshua L RoffmanDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
Pedro Gp RosaLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Matthew D SacchetCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Raymond SalvadorFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Salvador SarróFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Theodore D SatterthwaiteDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Mauricio H SerpaLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Kang SimWest Region, Institute of Mental Health, Singapore, Singapore.
Andrew SimmonsDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neurology, King's College London, London, UK.
Jordan W SmollerDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Iris E SommerDepartment of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Carles Soriano-MasCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Dan J SteinSAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa.
Lachlan T StrikeQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Philip R SzeszkoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Henk S TemminghDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alexander S TomyshevLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
Julian N TrollorCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Anne UhlmannDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Ilya M VeerDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Dick J VeltmanDepartment of Psychiatry & Amsterdam Neuroscience, Amsterdam UMC, location VUMC, Amsterdam, The Netherlands.
Aristotle VoineskosCampbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Lei WangDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Yang WangDepartment of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Bernd WeberInstitute for Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany.
Wei WenCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
John D WestDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Lars T WestlyeNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Heather C WhalleyDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Steven Cr WilliamsDepartment of Neuroimaging, King's College London, London, UK.
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Daniel H WolfDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Yuliya N YonchevaDepartment of Child and Adolescent Psychiatry, NYU Child Study Center, Hassenfeld Children's Hospital at NYU Langone, New York, New York, USA.
Marcus V ZanettiLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Georg C ZieglerDivision of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
Greig I de ZubicarayFaculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Eveline A CroneInstitute of Psychology, Leiden University, Leiden, The Netherlands.
Sophia FrangouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christian K TamnesNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Oslo University Hospital · NOCentro de Investigación Biomédica en Red de Salud Mental · ESAmsterdam Neuroscience · NLRadboud University Nijmegen · NLHeidelberg University · DEHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRKing's College London · GBUNSW Sydney · AUOllscoil na Gaillimhe – University of Galway · IEUniversitätsmedizin Greifswald · DEUniversity of Southern California · USVrije Universiteit Amsterdam · NLWestern Cape Department of Health · ZAHarvard University · USIndiana University School of MedicineLeiden University · NLNorwegian Institute of Public Health · NOUniversity Medical Center Groningen · NLUniversity of Würzburg · DEYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HALL, JANET E · 1985 to 2008
$37.4M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
FUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Translational Imaging and Behavioral Assessment (TIBA) CoreP20GM130447 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Anna Dunaevsky · 2020 to 2026
$20.7M
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 1999 to 2011
$16.4M
Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI BEDRICK, EDWARD J · 2012 to 2017
$14.3M
STRUCTURE, FUNCTION AND COGNITION IN SCHIZOPHRENIAP50MH071616 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2004 to 2008
$11.2M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
CIHR 287378CIHR FRN114887CIHR FRN126053Department of Health NF-SI-0616-10040Department of Health NIHR/MRC (14/23/17)European Research Council ERC-2010-StG-263234European Research Council ERC-230374Medical Research Council G0300189Medical Research Council G03001896 to J KuntsiMedical Research Council G0500092Medical Research Council MC_PC_17209Medical Research Council MR/S035818/1NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA129769NCRR NIH HHS M01 RR001066NCRR NIH HHS P41 RR014075NCRR NIH HHS U24 RR021992NCRR NIH HHS UL1 RR025761NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG058854NIA NIH HHS R01 AG059874NIA NIH HHS R03 AG064001NIA NIH HHS R03AG064001NIA NIH HHS R56 AG058854NIA NIH HHS RF1 AG057892NIA NIH HHS T32 AG058507NIA NIH HHS T32AG058507NIA NIH HHS U01 AG068057NIBIB NIH HHS R01 EB000840NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020062NIBIB NIH HHS R01 EB020407NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD050735NIGMS NIH HHS P20 GM103472NIGMS NIH HHS P20 GM130447NIGMS NIH HHS P20GM130447NIH HHS R56 AG058NIH HHS U54EB020403NIMH NIH HHS 5T32MH073526NIMH NIH HHS K01 MH099232NIMH NIH HHS K08 MH068540NIMH NIH HHS K23 MH085096NIMH NIH HHS K23 MH115206NIMH NIH HHS K24 MH094614NIMH NIH HHS P50 MH071616NIMH NIH HHS R00 MH101367NIMH NIH HHS R01 MH056584NIMH NIH HHS R01 MH059259NIMH NIH HHS R01 MH062873NIMH NIH HHS R01 MH083246NIMH NIH HHS R01 MH084803NIMH NIH HHS R01 MH085604NIMH NIH HHS R01 MH096957NIMH NIH HHS R01 MH101111NIMH NIH HHS R01 MH101486NIMH NIH HHS R01 MH101495NIMH NIH HHS R01 MH104284NIMH NIH HHS R01 MH106324NIMH NIH HHS R01 MH113619NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117014NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH118695NIMH NIH HHS R01 MH119219NIMH NIH HHS R01 MH119243NIMH NIH HHS R01 MH120080NIMH NIH HHS R01 MH120482NIMH NIH HHS R01 MH129742NIMH NIH HHS R37 MH085953NIMH NIH HHS R37 MH101495NIMH NIH HHS RC1 MH089257NIMH NIH HHS T32 MH073526NIMH NIH HHS U01 MH097435NINDS NIH HHS U01 NS105509Wellcome TrustWellcome Trust 064846Wellcome Trust 104036/Z/14/ZWellcome Trust 216767/Z/19/Z
6 · The paper itself

Abstract

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.

Indexed as

Biological Variation, PopulationBrainHuman DevelopmentMagnetic Resonance ImagingNeuroimagingSex CharacteristicsBrain Cortical ThicknessCerebral CortexFemaleHumansMale

Identifiers

PMID33044802
PMCPMC8675415
OpenAlexW3092108477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.