Evidence map›Paper›PMID 33044615›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures.

Marwa Elhady, Eman R Youness, Mones M AbuShady, Maysa S Nassar, Ali Abd Elaziz, Mahmoud M Masoud, Fayez K Foudaa, Walaa Alshasrany Abu Elhamed

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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Blood biomarkers in epilepsy.Acta neurologica Scandinavica · 2022
    Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marwa ElhadyPediatric Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, 11735, Egypt. Marwaelhady93@yahoo.com.ORCID 0000-0002-7785-3736
Eman R YounessMedical Biochemistry Department, National Research Centre, Cairo, Egypt.
Mones M AbuShadyChild Health Department, National Research Centre, Cairo, Egypt.
Maysa S NassarChild Health Department, National Research Centre, Cairo, Egypt.
Ali Abd ElazizChild Health Department, National Research Centre, Cairo, Egypt.
Mahmoud M MasoudMedical Biochemistry Department, National Research Centre, Cairo, Egypt.
Fayez K FoudaaMedical Biochemistry Department, National Research Centre, Cairo, Egypt.
Walaa Alshasrany Abu ElhamedDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
National Research Centre · EGAl-Azhar University · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpilepsy is a common neurological disease that has a negative impact on physical, social, and cognitive function. Seizure-induced neuronal injury is one of the suggested mechanisms of epilepsy complications. We aimed to evaluate the circulating level of glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) as markers of neuronal damage in children with epilepsy and its relation to epilepsy characteristics. STUDY

design

methodsThis case control study included 30 children with epilepsy and 30 healthy children as a control group. Seizure severity was determined based on Chalfont score. Serum level of GFAP and UCH-L1were measured, and their associations with epilepsy characteristics were investigated.

resultsCirculating levels of GFAP and UCH-L1 were significantly higher in children with epilepsy than in controls (17.440 ± 6.74 and 5.700 ± 1.64 vs 7.06 ± 3.30 and 1.81 ± 0.23, respectively) especially in those with generalized and active seizures. GFAP and UCH-L1 were significantly correlated to the severity of seizures in the previous 6 months. Elevated GFAP level was a predictor for active seizures (OR 1.841, 95%CI 1.043-3.250, P = 0.035).

conclusionCirculating GFAP and UCH-L1 expression is increased in children with epilepsy especially those with active seizures. SIGNIFICANCE: GFAP and UCH-L 1may serve as peripheral biomarkers for neuronal damage in children with epilepsy that can be used to monitor disease progression and severity for early identification of those with drug-resistant epilepsy and those who are in need for epilepsy surgery.

Indexed as

EpilepsyUbiquitin ThiolesteraseBiomarkersCase-Control StudiesChildGlial Fibrillary Acidic ProteinHumansSeizuresBiomarkersGlial Fibrillary Acidic ProteinUbiquitin ThiolesteraseUCHL1 protein, humanChildrenEpilepsyGFAPUCH-L1

Identifiers

PMID33044615
OpenAlexW4245584998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.