ReviewCurrent opinion in critical care2020
Identification of acute kidney injury subphenotypes.
Review in Current opinion in critical care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Electronic Phenotype for Detection, Staging, and Subtyping of Acute Kidney Injury.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Article
- Phenotypes of Dialysis-Requiring Acute Kidney Injury and Associations with Mortality in a South American Population.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- The Beneficial Effects of Mesenchymal Stem Cells in Acute Kidney Injury: A Narrative Review.Current stem cell research & therapy · 2024Review
- Definitions, phenotypes, and subphenotypes in acute kidney injury-Moving towards precision medicine.Nephrology (Carlton, Vic.) · 2023Review
- Acute kidney injury.Intensive care medicine · 2023Article
- Integration of artificial intelligence and multi-omics in kidney diseases.Fundamental research · 2023Review
- Gene signature for the prediction of the trajectories of sepsis-induced acute kidney injury.Critical care (London, England) · 2022Article
- Machine Learning for Acute Kidney Injury Prediction in the Intensive Care Unit.Advances in chronic kidney disease · 2022Review
- Unsupervised clustering reveals phenotypes of AKI in ICU COVID-19 patients.Frontiers in medicine · 2022Article
- Interpretable Sub-phenotype Identification in Acute Kidney Injury.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2022Article
- Identification of hub genes associated with acute kidney injury induced by renal ischemia-reperfusion injury in mice.Frontiers in physiology · 2022Article
- Biomarkers of acute kidney injury: time to learn from implementations.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewAKI is a complex clinical syndrome with many causes and there is a broad range of clinical presentations that vary according to duration, severity and context. Established consensus definitions of AKI are nonspecific and limited to kidney function. This reduces treatment options to generic approaches rather than individualized, cause-based strategies that have limited both understanding and management of AKI. RECENT
findingsThe context and the temporal phase of kidney injury are critical features in the course of AKI and critical to timing-relevant intervention. These features are missing in generic definitions and terms used to describe AKI. Subphenotypes of AKI can be identified from novel damage biomarkers, from functional changes including creatinine trajectories, from the duration of change and from associated clinical characteristics and comorbidities. Subphenotype parameters can be combined in risk scores, or by association strategies ranging from a simple function-damage matrix to complex methods, such as machine learning. Examples of such strategies are reviewed along with tentative proposals for a revised nomenclature to facilitate description of AKI subphenotypes. SUMMARY: Appropriate intervention requires refinement of the nomenclature of AKI to identify subphenotypes that facilitate correctly timed and selectively targeted intervention.
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Registered trials
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