Evidence map›Paper›PMID 33044170›Full record

ArticleeLife2020

Early prediction of level-of-care requirements in patients with COVID-19.

Boran Hao, Shahabeddin Sotudian, Taiyao Wang, Tingting Xu, Yang Hu, Apostolos Gaitanidis, Kerry Breen, George C Velmahos, Ioannis Ch Paschalidis

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Boran Hao *Center for Information and Systems Engineering, Boston University, Boston, United States.
Shahabeddin Sotudian *Center for Information and Systems Engineering, Boston University, Boston, United States.ORCID 0000-0002-5864-6192
Taiyao Wang *Center for Information and Systems Engineering, Boston University, Boston, United States.ORCID 0000-0002-0331-3892
Tingting Xu *Center for Information and Systems Engineering, Boston University, Boston, United States.
Yang HuCenter for Information and Systems Engineering, Boston University, Boston, United States.
Apostolos GaitanidisDivision of Trauma, Emergency Services, and Surgical Critical Care Massachusetts General Hospital, Harvard Medical School, Boston, United States.
Kerry BreenDivision of Trauma, Emergency Services, and Surgical Critical Care Massachusetts General Hospital, Harvard Medical School, Boston, United States.
George C VelmahosDivision of Trauma, Emergency Services, and Surgical Critical Care Massachusetts General Hospital, Harvard Medical School, Boston, United States.
Ioannis Ch PaschalidisCenter for Information and Systems Engineering, Boston University, Boston, United States.ORCID 0000-0002-3343-2913
Boston University · USHarvard University · US

Funding

Optimizing and Learning Strategies for Protein Docking R01GM135930 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI VAKILI, PIROOZ · 2019 to 2021
$561k
National Science Foundation CNS-1645681National Science Foundation DMS-1664644National Science Foundation IIS-1914792NIGMS NIH HHS R01 GM135930NIH HHS UL54 TR004130Office of Naval Research N00014-19-1-2571
6 · The paper itself

Abstract

This study examined records of 2566 consecutive COVID-19 patients at five Massachusetts hospitals and sought to predict level-of-care requirements based on clinical and laboratory data. Several classification methods were applied and compared against standard pneumonia severity scores. The need for hospitalization, ICU care, and mechanical ventilation were predicted with a validation accuracy of 88%, 87%, and 86%, respectively. Pneumonia severity scores achieve respective accuracies of 73% and 74% for ICU care and ventilation. When predictions are limited to patients with more complex disease, the accuracy of the ICU and ventilation prediction models achieved accuracy of 83% and 82%, respectively. Vital signs, age, BMI, dyspnea, and comorbidities were the most important predictors of hospitalization. Opacities on chest imaging, age, admission vital signs and symptoms, male gender, admission laboratory results, and diabetes were the most important risk factors for ICU admission and mechanical ventilation. The factors identified collectively form a signature of the novel COVID-19 disease.

Indexed as

BetacoronavirusHealth Services Needs and DemandPandemicsAdultAgedArea Under CurveBody Mass IndexComorbidityCoronavirus InfectionsCOVID-19Diabetes MellitusFemaleHospitalizationHumansIntensive Care UnitsMaleartificial intelligenceCOVID-19critical carehumaninfectious diseasemachine learningmedicinemicrobiologyrisk predictionSARS-CoV-2

Identifiers

PMID33044170
PMCPMC7595731
OpenAlexW3092208592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.