Evidence map›Paper›PMID 33044169›Full record

ArticleeLife2020

Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells.

Jiajia Xu, Yiyun Wang, Ching-Yun Hsu, Stefano Negri, Robert J Tower, Yongxing Gao, Ye Tian, Takashi Sono, Carolyn A Meyers, Winters R Hardy and 6 more

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Blood Vessel Resident Human Stem Cells in Health and Disease.Stem cells translational medicine · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jiajia Xu *Departments of Pathology, Johns Hopkins University, Baltimore, United States.ORCID 0000-0002-6084-2029
Yiyun Wang *Departments of Pathology, Johns Hopkins University, Baltimore, United States.
Ching-Yun HsuDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Stefano NegriDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Robert J TowerDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Yongxing GaoDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Ye TianDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Takashi SonoDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Carolyn A MeyersDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Winters R HardyDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Leslie ChangDepartments of Pathology, Johns Hopkins University, Baltimore, United States.
Shuaishuai HuUCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, United States.
Nusrat KahnUCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, United States.
Kristen BroderickDepartments of Plastic Surgery, Johns Hopkins University, Baltimore, United States.
Bruno PéaultUCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, United States.
Aaron W JamesDepartments of Pathology, Johns Hopkins University, Baltimore, United States.ORCID 0000-0002-2002-622X

Funding

Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
Role of sensory nerves in cranial bone repairR21DE027922 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CLEMENS, THOMAS L, JAMES, AARON W · 2018 to 2019
$450k
Chief Scientist Office CGA/18/33Medical Research Council G1000816Medical Research Council MR/K017047/1NIAMS NIH HHS K08 AR068316NIAMS NIH HHS R01 AR070773NIDCR NIH HHS R21 DE027922
6 · The paper itself

Abstract

Tissue resident mesenchymal stem/stromal cells (MSCs) occupy perivascular spaces. Profiling human adipose perivascular mesenchyme with antibody arrays identified 16 novel surface antigens, including endolysosomal protein CD107a. Surface CD107a expression segregates MSCs into functionally distinct subsets. In culture, CD107a

Indexed as

AdipocytesAdipogenesisAnimalsCell DifferentiationHumansLysosomal-Associated Membrane Protein 1MaleMesenchymal Stem CellsMiceMice, Inbred NODMice, SCIDOsteogenesisRatsRats, NudeStem CellsLysosomal-Associated Membrane Protein 1adipogenesisCD107a/LAMP1exocytosishumanmedicinemesenchymal stem cellmouseosteogenesisperivascular stem cellratregenerative medicinestem cells

Identifiers

PMID33044169
PMCPMC7550188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.