ArticleJournal of applied clinical medical physics2020
Technical Note: Comparison of the internal target volume (ITV) contours and dose calculations on 4DCT, average CBCT, and 4DCBCT imaging for lung stereotactic body radiation therapy (SBRT).
Article in Journal of applied clinical medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 13 citations in OpenAlex.
- Margin for compensating displacement of adrenal gland metastasis and fiducial marker along with respiratory phase in real-time motion-tracking radiation therapy.Radiological physics and technology · 2025Article
- Effect of respiration-induced motion on a three-dimensional magnetic resonance imaging-based adaptive radiotherapy workflow in a 1.5T magnetic resonance linear accelerator.Quantitative imaging in medicine and surgery · 2025Article
- Safety and efficiency of a fully automatic workflow for auto-segmentation in radiotherapy using three commercially available deep learning-based applications.Physics and imaging in radiation oncology · 2024Article
- Evaluation of dose delivery based on deformed CT using a commercial software for lung cancer.Scientific reports · 2024Article
- Impact of different respiratory gating methods on target delineation and a radiotherapy plan for solitary pulmonary tumors.Cancer medicine · 2024Article
- A four-dimensional dynamic conformal arc approach for real-time tumor tracking: A retrospective treatment planning study.Journal of applied clinical medical physics · 2024Article
- Stereotactic body radiation therapy to the spine: contouring the cauda equina instead of the spinal cord is more practical as the organ at risk.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Article
- Intrafraction target shift comparison using two breath-hold systems in lung stereotactic body radiotherapy.Physics and imaging in radiation oncology · 2022Article
- Deep Learning-Based Internal Target Volume (ITV) Prediction Using Cone-Beam CT Images in Lung Stereotactic Body Radiotherapy.Technology in cancer research & treatmentArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo investigate the differences between internal target volumes (ITVs) contoured on the simulation 4DCT and daily 4DCBCT images for lung cancer patients treated with stereotactic body radiotherapy (SBRT) and determine the dose delivered on 4D planning technique.
methodsFor nine patients, 4DCBCTs were acquired before each fraction to assess tumor motion. An ITV was contoured on each phase of the 4DCBCT and a union of the 10 ITVs was used to create a composite ITV. Another ITV was drawn on the average 3DCBCT (avgCBCT) to compare with current clinical practice. The Dice coefficient, Hausdorff distance, and center of mass (COM) were averaged over four fractions to compare the ITVs contoured on the 4DCT, avgCBCT, and 4DCBCT for each patient. Planning was done on the average CT, and using the online registration, plans were calculated on each phase of the 4DCBCT and on the avgCBCT. Plan dose calculations were tested by measuring ion chamber dose in the CIRS lung phantom.
resultsThe Dice coefficients were similar for all three comparisons: avgCBCT-to-4DCBCT (0.7 ± 0.1), 4DCT-to-avgCBCT (0.7 ± 0.1), and 4DCT-to-4DCBCT (0.7 ± 0.1); while the mean COM differences were also comparable (2.6 ± 2.2mm, 2.3 ± 1.4mm, and 3.1 ± 1.1mm, respectively). The Hausdorff distances for the comparisons with 4DCBCT (8.2 ± 2.9mm and 8.1 ± 3.2mm) were larger than the comparison without (6.5 ± 2.5mm). The differences in ITV D95% between the treatment plan and avgCBCT calculations were 4.3 ± 3.0% and -0.5 ± 4.6%, between treatment plan and 4DCBCT plans, respectively, while the ITV V100% coverages were 99.0 ± 1.9% and 93.1 ± 8.0% for avgCBCT and 4DCBCT, respectively.
conclusionThere is great potential for 4DCBCT to evaluate the extent of tumor motion before treatment, but image quality challenges the clinician to consistently delineate lung target volumes.
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