ArticleeLife2020
DMT alters cortical travelling waves.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 82 citations in OpenAlex.
- A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial.Nature medicine · 2026Trial
- Psychological and physiological effects of extended DMT.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Trial
- Moving beyond 5-HTPsychopharmacology · 2026Article
- Reorganization of Human Brain Waves Across Diverse States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Propofol-induced loss of responsiveness reorganizes cortical traveling waves in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Learning as the unifying mechanism of psychedelic action.Journal of psychopharmacology (Oxford, England) · 2026Review
- Article
- Psilocybin shapes the slow, global propagation of brain activity over the cortical layout of 5HT2a receptors.Communications biology · 2026Article
- Preliminary analysis of ayahuasca-induced anatomical alterations in the somatosensory cortex of juvenile non-human primates (Callithrix jacchus) subjected to chronic stress.Translational psychiatry · 2026Article
- Backward alpha band oscillations shape perceptual bias under probabilistic cues.Communications biology · 2026Article
- Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex.Communications biology · 2026Article
- Perceptual Bias in Motion Discrimination is Related to Asymmetric Interhemispheric Alpha Traveling Waves.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.Psychopharmacology · 2025Review
- Experienced meditators show greater forward traveling cortical alpha wave strengths.Annals of the New York Academy of Sciences · 2025Article
- Fronto-occipital dyscommunication associates with brain hierarchy in schizophrenia.Communications biology · 2025Article
- Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings.STAR protocols · 2025Article
- From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS).Scientific reports · 2025Article
- Eigenmodes of the deep unconscious: the neuropsychology of Jungian archetypes and psychedelic experience.Neuroscience of consciousness · 2025Review
- LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology. N,N, Dimethyltryptamine (DMT) can rapidly induce an extremely immersive state of consciousness characterized by vivid and elaborate visual imagery. Here, we investigated the electrophysiological correlates of the DMT-induced altered state from a pool of participants receiving DMT and (separately) placebo (saline) while instructed to keep their eyes closed. Consistent with our hypotheses, results revealed a spatio-temporal pattern of cortical activation (i.e. travelling waves) similar to that elicited by visual stimulation. Moreover, the typical top-down alpha-band rhythms of closed-eyes rest were significantly decreased, while the bottom-up forward wave was significantly increased. These results support a recent model proposing that psychedelics reduce the 'precision-weighting of priors', thus altering the balance of top-down versus bottom-up information passing. The robust hypothesis-confirming nature of these findings imply the discovery of an important mechanistic principle underpinning psychedelic-induced altered states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.