ArticleJournal of dental research2021
Nonuniformity in Periodontal Ligament: Mechanics and Matrix Composition.
Article in Journal of dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- The Osteoimmune Axis: Immune-Mechanical Crosstalk in Periodontal Bone Remodeling.Biomolecules · 2026Article
- Biological mechanisms governing the periodontal regenerative microenvironment: cellular crosstalk, extracellular matrix remodelling, and immunomodulation.Frontiers in cell and developmental biology · 2026Review
- Chemical Digestion-Assisted Proteomics Reveals the Extracellular Matrix Profile of Human Periodontal Ligament and its Alterations in Cultured Cell-Derived Extracellular Matrix.Molecular & cellular proteomics : MCP · 2025Article
- Exploring the mechanical and biological interplay in the periodontal ligament.International journal of oral science · 2025Review
- Article
- Formulation of Hyperelastic Constitutive Model for Human Periodontal Ligament Based on Fiber Volume Fraction.Materials (Basel, Switzerland) · 2025Article
- Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement.BMC oral health · 2024Article
- Type VI Collagen Deficiency Causes Enhanced Periodontal Tissue Destruction.Journal of dental research · 2024Article
- Harnessing Mechanical Stress with Viscoelastic Biomaterials for Periodontal Ligament Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multiomics analysis of cultured mouse periodontal ligament cell-derived extracellular matrix.Scientific reports · 2024Article
- Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges.Frontiers in bioengineering and biotechnology · 2024Review
- Nociceptor mechanisms underlying pain and bone remodeling via orthodontic forces: toward no pain, big gain.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Construction of Human Periodontal Ligament Constitutive Model Based on Collagen Fiber Content.Materials (Basel, Switzerland) · 2023Article
- Obesity Modifies the Proteomic Profile of the Periodontal Ligament.International journal of molecular sciences · 2023Article
- Biomechanical factors in the open gingival embrasure region during the intrusion of mandibular incisors: A new model through finite element analysis.Frontiers in bioengineering and biotechnology · 2023Article
- The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects.Maxillofacial plastic and reconstructive surgery · 2022Review
- A new direction in managing avulsed teeth: stem cell-based de novo PDL regeneration.Stem cell research & therapy · 2022Review
- Extracellular Matrix-Oriented Proteomic Analysis of Periodontal Ligament Under Mechanical Stress.Frontiers in physiology · 2022Article
- From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues.Biomolecules · 2021Review
- In vivo cell proliferation analysis and cell-tracing reveal the global cellular dynamics of periodontal ligament cells under mechanical-loading.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The periodontal ligament (PDL) plays a critical role in providing immediate response to abrupt high loads during mastication while also facilitating slow remodeling of the alveolar bone. The PDL exceptional functionality is permitted by the unique nonuniform structure of the tissue. Two distinct areas that are critical to PDL function were previously identified: the furcation and the dense collar. Despite their hypothesized functions in tooth movement and maintenance, these 2 regions have not yet been compared within the context of their native environment. Therefore, the objective of this study is to elucidate the extracellular matrix (ECM) structure, composition, and biomechanical function of the furcation and the collar regions while maintaining the 3-dimensional (3D) structure in the murine PDL. We identify significant difference between the collar and furcation regions in both structure and mechanical properties. Specifically, we observed unique longitudinal structures in the dense collar that correlate with type VI collagen and LOX, both of which are associated with increased type I collagen density and tissue stiffness and are therefore proposed to function as scaffolds for tooth stabilization. We also found that the collar region is stiffer than the furcation region and therefore suggest that the dense collar acts as a suspense structure of the tooth within the bone during physiological loading. The furcation region of the PDL contained more proteins associated with reduced stiffness and higher tissue remodeling, as well as a dual mechanical behavior, suggesting a critical function in loads transfer and remodeling of the alveolar bone. In summary, this work unravels the nonuniform nature of the PDL within the 3D structural context and establishes understanding of regional PDL function, which opens new avenues for future studies of remodeling, regeneration, and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.