ArticleAmerican journal of Alzheimer's disease and other dementias
Low Hippocampal Dentate Gyrus Volume Associated With Hypertension-Related Cognitive Impairment.
Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Neuroscience meets behavior: A systematic literature review on magnetic resonance imaging of the brain combined with real-world digital phenotyping.Human brain mapping · 2024Pooled it
- Shichangpu-Xiyangshen Herb Extract Alleviates Cognitive Dysfunction in Type 1 Diabetes Through Metabolism of Arachidonic Acid Cyclooxygenase and Lipoxygenase.Molecules (Basel, Switzerland) · 2026Article
- Association Between Carotid Atherosclerosis and Post-Stroke Cognitive Impairment in Patients With Mild Ischemic Stroke: A Prospective Cohort Study.CNS neuroscience & therapeutics · 2026Article
- Alterations of contralesional hippocampal subfield volumes and relations to cognitive functions in patients with unilateral stroke.Brain and behavior · 2024Article
- Alterations in regional homogeneity and functional connectivity associated with cognitive impairment in patients with hypertension: a resting-state functional magnetic resonance imaging study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Relations of hippocampal subfields atrophy patterns with memory and biochemical changes in end stage renal disease.Scientific reports · 2023Article
- The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation.Frontiers in cardiovascular medicine · 2022Review
- Hypertension Status Moderated the Relationship between the Hippocampal Subregion of the Left GC-ML-DG and Cognitive Performance in Subjective Cognitive Decline.Disease markers · 2022Article
- Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension increases the risk of cognitive impairment independent of detectable stroke or cerebral lesions. However, the principal pathophysiological basis of this increase has not been fully elucidated. The present study investigates the relationships among blood pressure, hippocampal subfields volume, and cognitive function in a relatively young non-stroke population. A total of 59 non-stroke non-dementia subjects (mean age, 57.2 ± 4.9 years) were enrolled. All subjects were subjected to complete assessment of vascular risk factors including 24-hour blood pressure monitoring, various neuropsychological tests, and 3D-T1 MR scan. Freesurfer V6.0 was used for segmentation of hippocampal subfields. Our analyses revealed that both 24-hour and daytime mean systolic blood pressure (SBP) were significantly associated with the low volume of the left DG. Higher coefficient of variation (CV) of daytime SBP was significantly associated with lower volume of the left Cornu Ammonis 4 and dentate gyrus (DG) region. Both higher CV of 24-hour mean SBP and daytime SBP were significantly associated with lower performance in both executive and linguistic function. The low volume of the left DG was significantly associated with the low performance in linguistic function. Our findings support that reduced DG volume and increased SBP variability associated with hypertension-related cognitive impairment.
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Registered trials
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