ArticleStem cells translational medicine2021
Synergistic effect of nanofat and mouse nerve-growth factor for promotion of sensory recovery in anterolateral thigh free flaps.
Article in Stem cells translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Boosting the vascularization and regenerative capacity of nanofat by short-term ex vivo pretreatment with erythropoietin.Journal of translational medicine · 2026Article
- Review
- Allicin-loaded hydrogel enhances the viability of multiterritory perforator flap.Materials today. Bio · 2025Article
- Precision approach to diabetic peripheral neuropathy: modified nerve decompression surgery and MNGF treatment.Frontiers in medicine · 2025Article
- Strategies for Treating Traumatic Neuromas with Tissue-Engineered Materials.Biomolecules · 2024Review
- Functional donor-site morbidity following reconstruction with pectoralis major flaps: A systematic review.JPRAS open · 2024Review
- [Discussion on surgical treatment mode of diabetic foot wounds].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation.Aesthetic surgery journal. Open forum · 2023Article
- Mouse Nerve Growth Factor Injection and Progression Rate in Patients With Amyotrophic Lateral Sclerosis: An Observational Study.Frontiers in neurology · 2022Article
- Synergistic effect of nanofat and mouse nerve-growth factor for promotion of sensory recovery in anterolateral thigh free flaps.Stem cells translational medicine · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anterolateral thigh (ALT) free flaps are widely used for reconstruction, but poor sensory recovery of the flap tissue can cause unsatisfactory outcomes and poor function. Adipose-derived mesenchymal stem cells (ADSCs) promote neural regeneration, but the clinical use of stem-cell therapy has been limited by lack of regulatory approval. Nanofat is an autologous product that is prepared mechanically from harvested fat. It is enriched in ADSCs and does not contain any exogenous substances. The developmental and adult neurobiology of nerve-growth factor (NGF) are well investigated, and mouse (m)NGF has been used to promote recovery following peripheral nerve injury. We investigated the promotion of nanofat and mNGF as either mono- or combined therapy on the sensory recovery of ALT free flaps. We found that nanofat and mNGF had a synergistic effect on sensory recovery that was associated with stimulation of angiogenesis and neurogenesis. Nanofat combined with mNGF was better at promoting neural regeneration and improving sensory recovery than treatment with either agent alone. The results provide a theoretical rationale for further study of the clinical use of nanofat combined with mNGF to promote the sensory recovery of ALT free flaps.
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