Evidence map›Paper›PMID 33043579›Full record

ArticleJournal of cellular and molecular medicine2020

Inhibition of IRE1/JNK pathway in HK-2 cells subjected to hypoxia-reoxygenation attenuates mesangial cells-derived extracellular matrix production.

Yan Liang, Lulu Liang, Zhenjie Liu, Yingzi Wang, Xiubing Dong, Lingyun Qu, Rong Gou, Yulin Wang, Qian Wang, Zhangsuo Liu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

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  15. Roles of SIRT6 in kidney disease: a novel therapeutic target.Cellular and molecular life sciences : CMLS · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yan LiangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lulu LiangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhenjie LiuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yingzi WangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiubing DongDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lingyun QuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Rong GouDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yulin WangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Qian WangResearch Institute of Nephrology, Zhengzhou University, Zhengzhou, China.
Zhangsuo LiuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-2916-8371
Lin TangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-2068-3123
Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress and inflammatory responses play active roles in the transition of acute kidney injury (AKI) to chronic kidney disease (CKD). Inositol-requiring enzyme 1 (IRE1) activates c-Jun NH

Indexed as

Cell HypoxiaAcute Kidney InjuryBiomarkersCytokinesDisease ProgressionDisease SusceptibilityEndoplasmic Reticulum StressEndoribonucleasesExtracellular MatrixFluorescent Antibody TechniqueGene Knockdown TechniquesHumansInflammation MediatorsJNK Mitogen-Activated Protein KinasesMesangial CellsOxygenBiomarkersCytokinesDDIT3 protein, humanEndoribonucleasesERN1 protein, humanInflammation MediatorsJNK Mitogen-Activated Protein KinasesOxygenProtein Serine-Threonine KinasesRNA, Small InterferingSTAT3 Transcription FactorTranscription Factor CHOPAKI-CKD transitionECMhypoxia-reoxygenationinflammationIRE1JNK

Identifiers

PMID33043579
PMCPMC7701502
OpenAlexW3091768366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.