ArticleEuropean journal of neurology2021
COVID-19 pandemic and mental distress in multiple sclerosis: Implications for clinical management.
Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Pooled it
- The psychological impact of Covid-19 pandemic on people with Multiple Sclerosis: A meta-analysis.Multiple sclerosis and related disorders · 2022Pooled it
- Psychological impacts of COVID-19 pandemic on individuals living with multiple sclerosis: A rapid systematic review.Multiple sclerosis and related disorders · 2022Pooled it
- The late onset of emotional distress in people with progressive multiple sclerosis during the Covid-19 pandemic: longitudinal findings from the CogEx study.Journal of neurology · 2022Trial
- Resilience as a Moderator of the Effects of Workplace Bullying on Psychological Distress and Sleep Quality Among Information Technology Professionals.International journal of environmental research and public health · 2025Article
- The Health-Related Quality of Life Impact of the COVID-19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ-5D-5L with Psychosocial Bolt-Ons.Brain and behavior · 2025Article
- COVID-19 and multiple sclerosis: challenges and lessons for patient care.The Lancet regional health. Europe · 2024Review
- The quality of life impact of the COVID-19 pandemic and lockdowns for people living with multiple sclerosis (MS): evidence from the Australian MS Longitudinal Study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Telerehabilitation and onsite rehabilitation effectively improve quality of life, fatigue, balance, and cognition in people with multiple sclerosis: an interventional study.Frontiers in neurology · 2024Article
- Sexual Dysfunction in People with Multiple Sclerosis: The Role of Disease Severity, Illness Perception, and Depression.Journal of clinical medicine · 2023Article
- Conceptualization, use, and outcomes associated with compassion in the care of people with multiple sclerosis: a scoping review.Journal of neurology · 2023Article
- Mental Health in Multiple Sclerosis During the COVID-19 Outbreak: A Delicate Balance between Fear of Contagion and Resilience.Journal of clinical psychology in medical settings · 2022Article
- Feelings of loneliness, COVID-19-specific-health anxiety and depressive symptoms during the first COVID-19 wave in Swiss persons with multiple sclerosis.Scientific reports · 2022Article
- The influence of COVID-19 pandemic lockdown on the physical activity of people with multiple sclerosis. The role of online training.Multiple sclerosis and related disorders · 2022Article
- Association between relapses, stress, and depression in people with multiple sclerosis during the COVID-19 pandemic.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Impact of COVID-19 lockdown on progressive multiple sclerosis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Association between relapses, stress, and depression in people with multiple sclerosis during the COVID-19 pandemic.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Surviving a global pandemic: The experience of depression, anxiety, and loneliness among individuals with multiple sclerosis.Multiple sclerosis and related disorders · 2022Article
- Mental Health Status of People with Multiple Sclerosis during the COVID-19 Pandemic.Journal of clinical medicine · 2022Article
- Perception of COVID-19 Pandemic by Brazilian People With Parkinson's Disease and Multiple Sclerosis.Frontiers in psychology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIn multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiatric symptoms in an Italian MS population during the COVID-19 lockdown, in order to identify potentially modifiable factors that could inform clinical management of mental distress in people with MS.
methodsWe explored the relationship between mental distress, disability and coping strategies in the Italian MS population under lockdown. Structural equation modeling was applied to information collected via web survey to identify modifiable factors that could account for mental distress.
resultsA total of 845 participants (497 with MS and 348 controls) were included in the study. The MS group had higher scores than the control group for depression (p = 0.005), but not for anxiety, emotional dyscontrol or sleep disturbances. The structural equation modeling explained 74% of the variance observed in depression score. Within the model, three latent factors were characterized from measured variables: motor disability and cognitive dysfunction contributed to disability (β = 0.509 and β = 0.836; p < 0.001); positive attitude and exercise contributed to active attitude (β = 0.386 and β = 0.297; p < 0.001); and avoidance, social support and watching television contributed to passive attitude (β = 0.301, β = 0.243 and β = 0.212; p < 0.001). With regard to the relationship between latent factors and their influence on depression, disability contributed to passive attitude (β = 0.855; p < 0.001), while both passive and active attitude significantly influenced depression (β = 0.729 and β = -0.456; p < 0.001).
conclusionAs a practical implication of our model, favoring exercise would enhance active attitude and its positive impact on mental well-being while, at the same time, reducing the negative impact of disability on depression, representing a valuable tool in facing COVID-19-related mental distress.
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