SynthesisEuropean journal of clinical investigation2021
Incidence and treatment of arrhythmias secondary to coronavirus infection in humans: A systematic review.
Synthesis in European journal of clinical investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Incidence and treatment of arrhythmias secondary to coronavirus infection in humans: A systematic review.European journal of clinical investigation · 2021Pooled it
- Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologies.Journal of molecular and cellular cardiology · 2025Review
- Pathophysiological correlations between SARS-CoV-2 and arrhythmogenesis: a literature review.Germs · 2024Review
- The incidence and impact of atrial fibrillation on hospitalized Coronavirus disease-2019 patients.Clinical cardiology · 2024Article
- Association of New-Onset Atrial Fibrillation With All-Cause Mortality in COVID-19 Patients.Cureus · 2023Article
- Outcomes in patients with COVID-19 and new onset heart blocks: Insight from the National Inpatient Sample database.World journal of cardiology · 2023Article
- Relationship between rheumatoid arthritis and cardiovascular comorbidity, causation or co-occurrence: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Evaluation of a Wearable in-Ear Sensor for Temperature and Heart Rate Monitoring: A Pilot Study.Journal of medical systems · 2022Article
- COVID-19 and the cardiovascular system: an update.The American journal of the medical sciences · 2022Review
- The Potential Impact of COVID-19 Virus on the Heart and the Circulatory System.Infection and drug resistance · 2022Review
- Cardiac Manifestations in Patients with COVID-19: A Scoping Review.Global heart · 2022Article
- COVID-19 and the CHAClinical medicine & research · 2021Article
- Cardiac complications during the active phase of COVID-19: review of the current evidence.Internal and emergency medicine · 2021Review
- COVID-19 pandemic and reasons to prioritize the needs of the health care system to ensure its sustainability: A scoping review from January to October 2020 (Review).Experimental and therapeutic medicine · 2021Article
- Contemporary approach to understand and manage COVID-19-related arrhythmia.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2021Review
- Current systematic reviews and meta-analyses of COVID-19.World journal of virology · 2021Article
- Pericardial Diseases in COVID19: a Contemporary Review.Current cardiology reports · 2021Review
- SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function.Stem cell reports · 2021Article
- Validation and Reliability of a Novel Vagus Nerve Neurodynamic Test and Its Effects on Heart Rate in Healthy Subjects: Little Differences Between Sexes.Frontiers in neuroscience · 2021Article
- Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID-19.European journal of clinical investigation · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide resulting in significant morbidity and mortality. Arrhythmias are prevalent and reportedly, the second most common complication. Several mechanistic pathways are proposed to explain the pro-arrhythmic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A number of treatment approaches have been trialled, each with its inherent unique challenges. This rapid systematic review aimed to examine the current incidence and available treatment of arrhythmias in COVID-19, as well as barriers to implementation.
methodsOur search of scientific databases identified relevant published studies from 1 January 2000 until 1 June 2020. We also searched Google Scholar for grey literature. We identified 1729 publications of which 1704 were excluded.
resultsThe incidence and nature of arrhythmias in the setting of COVID-19 were poorly documented across studies. The cumulative incidence of arrhythmia across studies of hospitalised patients was 6.9%. Drug-induced long QT syndrome secondary to antimalarial and antimicrobial therapy was a significant contributor to arrhythmia formation, with an incidence of 14.15%. Torsades de pointes (TdP) and sudden cardiac death (SCD) were reported. Treatment strategies aim to minimise this through risk stratification and regular monitoring of corrected QT interval (QTc).
conclusionPatients with SARS-CoV-2 are at an increased risk of arrhythmias. Drug therapy is pro-arrhythmogenic and may result in TdP and SCD in these patients. Risk assessment and regular QTc monitoring are imperative for safety during the treatment course. Further studies are needed to guide future decision-making.
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