ArticleJournal of thrombosis and thrombolysis2021
Platelet microvesicles are associated with the severity of coronary artery disease: comparison between peripheral and coronary circulation.
Article in Journal of thrombosis and thrombolysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction.Circulation · 2026Article
- Multicomponent-based analyses of ACS-patient-derived extracellular vesicles as likely tools for tailored interventional approaches.iScience · 2025Article
- Developing technologies to assess vascular ageing: a roadmap from VascAgeNet.Physiological measurement · 2024Review
- Circulating microvesicles across a population with various degree of cardiovascular burden are associated with systolic blood pressure.Journal of human hypertension · 2023Review
- Circulating Small Extracellular Vesicles Reflect the Severity of Myocardial Damage in STEMI Patients.Biomolecules · 2023Article
- Pravastatin reduces plasma levels of extracellular vesicles in pregnancies at high risk of term preeclampsia.Frontiers in pharmacology · 2023Article
- New factors in heart failure pathophysiology: Immunity cells release of extracellular vesicles.Frontiers in cardiovascular medicine · 2022Article
- Endothelial Dysfunction in Psoriasis: An Updated Review.Frontiers in medicine · 2022Review
- Radiovesicolomics-new approach in medical imaging.Frontiers in physiology · 2022Review
- Patients with autoimmune chronic inflammatory diseases present increased biomarkers of thromboinflammation and endothelial dysfunction in the absence of flares and cardiovascular comorbidities.Journal of thrombosis and thrombolysis · 2022Article
- Molecular Advances in Hypertension and Blood.International journal of molecular sciences · 2021Article
- Platelet Mediated Inflammation in Coronary Artery Disease with Type 2 Diabetes Patients.Journal of inflammation research · 2021Article
- Assessment of Endothelial Injury and Pro-Coagulant Activity Using Circulating Microvesicles in Survivors of Allogeneic Hematopoietic Cell Transplantation.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microvesicles (MVs) have recently emerged as markers of thrombosis. Furthermore, there is an unexplained residual thrombotic risk is observed in patients with acute coronary syndrome (ACS) and/or stable coronary artery disease (CAD), despite treatment. We measured platelet (PMVs) and erythrocyte (ErMVs) in patients with ACS and stable CAD, both in the peripheral and coronary circulation. We studied consecutive eligible patients during a coronary angiography. Blood samples were collected from the stem of the left coronary artery and femoral artery. PMVs were significantly increased in CAD patients compared to controls. ACS patients had also increased PMVs in coronary and peripheral circulation, compared to controls. Furthermore, ACS patients exhibited increased PMVs in coronary compared to peripheral circulation. Lastly, coronary PMVs were associated with the severity of CAD based on the SYNTAX score. No significant differences were observed in the levels of ErMVs among groups. Therefore, PMVs emerge as novel markers of thrombosis in CAD, further augmenting the vicious cycle of inflammation and thrombosis during ACS. Importantly, coronary PMVs may reflect the severity of CAD in this population.
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