ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Eye movement especially vertical oculomotor impairment as an aid to assess Parkinson's disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effectiveness of vestibular rehabilitation on postural balance in Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.BMC neurology · 2024Pooled it
- Exploring eye movement abnormalities as objective biomarkers for Parkinson's disease utilizing virtual reality-based eye tracking.BMC neurology · 2026Article
- EYE movement abnormalities in Parkinson's disease: optometric screening and rehabilitation.Clinical parkinsonism & related disorders · 2026Review
- Smooth pursuit eye movements in different directions and frequencies as biomarkers for detecting early stage Parkinson's disease and assessing levodopa responsiveness: a cross-sectional study.European journal of medical research · 2025Observational
- Biofeedback for Motor and Cognitive Rehabilitation in Parkinson's Disease: A Comprehensive Review of Non-Invasive Interventions.Brain sciences · 2025Review
- Eye Tracking in Parkinson's Disease: A Review of Oculomotor Markers and Clinical Applications.Brain sciences · 2025Review
- A Riemannian multimodal representation to classify parkinsonism-related patterns from noninvasive observations of gait and eye movements.Biomedical engineering letters · 2025Article
- Videonystagmography features and clinical symptoms correlate with Parkinson's clinical subtypes.Frontiers in neurology · 2025Article
- Oculomotor indicators of cognitive performance are modulated by neurodegeneration.Frontiers in neurology · 2025Article
- Video-Oculography for Enhancing the Diagnostic Accuracy of Early Oculomotor Dysfunction in Progressive Supranuclear Palsy.Journal of movement disorders · 2025Article
- Different patterns of acute saccadic response to levodopa in de novo Parkinson's disease.Journal of neurology · 2024Article
- Clinical value of video oculomotor evaluation in the differential diagnosis of multiple system atrophy and Parkinson's disease.Brain and behavior · 2024Article
- Eye movement function captured via an electronic tablet informs on cognition and disease severity in Parkinson's disease.Scientific reports · 2024Article
- Effects of Cervical Spinal Manipulation on Saccadic Eye Movements.Brain sciences · 2024Article
- Eye tracking assessment of Parkinson's disease: a clinical retrospective analysis.Journal of medicine and life · 2024Article
- Oculomotor Dysfunction in Idiopathic and LRRK2-Parkinson's Disease and At-Risk Individuals.Journal of Parkinson's disease · 2024Article
- Oculometric measures as a tool for assessment of clinical symptoms and severity of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Machine Learning and Eye Movements Give Insights into Neurodegenerative Disease Mechanisms.Sensors (Basel, Switzerland) · 2023Review
- A novel tablet-based software for the acquisition and analysis of gaze and eye movement parameters: a preliminary validation study in Parkinson's disease.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo detect abnormal eye movements in Parkinson's disease and explore its correlation with clinical characteristics and their value for diagnosis.
methodsWe recruited forty-nine Parkinson's disease patients, including 35 early Parkinson's disease patients (Hoehn-Yahr: 1 to 2 stage) and 14 advanced Parkinson's disease patients (Hoehn-Yahr: 3 to 5 stage) and 23 healthy controls. Clinical manifestations in Parkinson's disease patients were recorded. Oculomotor performances including fixation, gaze, saccade in horizontal and vertical direction, and smooth pursuit in horizontal and vertical direction were measured by video-oculography.
resultsWe found that five oculomotor parameters, namely square wave jerk frequency, latency of downward saccade, latency of upward saccade, accuracy of upward saccade, and gain of horizontal smooth pursuit were significantly different in Parkinson's disease patients and controls. When combining all these five parameters, we got the diagnostic sensitivity of 78.3% and specificity of 95.2%. More deficits in upward saccade than in other directions were associated with disease duration and progression of Parkinson's disease.
conclusionOur primary study suggests that oculomotor examination might serve as an aid in the clinical assessment of Parkinson's disease patients and differentiating between early Parkinson's disease and normal controls.
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