ReviewPerspectives in ecology and conservation
Assessing the SARS-CoV-2 threat to wildlife: Potential risk to a broad range of mammals.
Review in Perspectives in ecology and conservation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Wildlife Viruses: Impact on Human and Animal Health.Viruses · 2024Article
- Widespread exposure to SARS-CoV-2 in wildlife communities.Nature communications · 2024Article
- Survey of severe acute respiratory syndrome coronavirus 2 in captive and free-ranging wildlife from Spain.Veterinary research · 2024Article
- Identification of SARS-CoV-2 in urban rodents from Southern Mexico City at the beginning of the COVID-19 pandemic.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Machine-learning prediction of hosts of novel coronaviruses requires caution as it may affect wildlife conservation.Nature communications · 2022Article
- SARS-CoV-2 transmission from infected owner to household dogs and cats is associated with food sharing.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Multi-species outbreak of SARS-CoV-2 Delta variant in a zoological institution, with the detection in two new families of carnivores.Transboundary and emerging diseases · 2022Article
- No molecular evidence of SARS-CoV-2 infection in companion animals from Veracruz, Mexico.Transboundary and emerging diseases · 2022Article
- Striking lineage diversity of severe acute respiratory syndrome coronavirus 2 from non-human sources.One health (Amsterdam, Netherlands) · 2022Article
- SARS-CoV-2 infection in free roaming dogs from the Amazonian jungle.One health (Amsterdam, Netherlands) · 2022Article
- Special Issue: Emerging Wildlife Viral Diseases.Viruses · 2022Article
- Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022Article
- Investigating SARS-CoV-2 Susceptibility in Animal Species: A Scoping Review.Environmental health insights · 2022Article
- SARS-CoV-2 in animals: potential for unknown reservoir hosts and public health implications.The veterinary quarterly · 2021Review
- Peridomestic Mammal Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection.Emerging infectious diseases · 2021Article
- SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.Cell host & microbe · 2021Article
- Animal Transmission of SARS-CoV-2 and the Welfare of Animals during the COVID-19 Pandemic.Animals : an open access journal from MDPI · 2021Review
- Investigating the Presence of SARS CoV-2 in Free-Living and Captive Animals.Pathogens (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect animals, however, the whole range of potential hosts is still unknown. This work makes an assessment of wildlife susceptibility to SARS-CoV-2 by analyzing the similarities of Angiotensin Converting Enzyme 2 (ACE2) and Transmembrane Protease, Serine 2 (TMPRSS2)-both recognized as receptors and protease for coronavirus spike protein-and the genetic variation of the viral protein spike in the recognition sites. The sequences from different mammals, birds, reptiles, and amphibians, and the sequence from SARS-CoV-2 S protein were obtained from the GenBank. Comparisons of aligned sequences were made by selecting amino acids residues of ACE2, TMPRSS2 and S protein; phylogenetic trees were reconstructed using the same sequences. The species susceptibility was ranked by substituting the values of amino acid residues for both proteins. Our results ranked primates at the top, but surprisingly, just below are carnivores, cetaceans and wild rodents, showing a relatively high potential risk, as opposed to lab rodents that are typically mammals at lower risk. Most of the sequences from birds, reptiles and amphibians occupied the lowest ranges in the analyses. Models and phylogenetic trees outputs showed the species that are more prone to getting infected with SARS-CoV-2. Interestingly, during this short pandemic period, a high haplotypic variation was observed in the RBD of the viral S protein, suggesting new risks for other hosts. Our findings are consistent with other published results reporting laboratory and natural infections in different species. Finally, urgent measures of wildlife monitoring are needed regarding SARS-CoV-2, as well as measures for avoiding or limiting human contact with wildlife, and precautionary measures to protect wildlife workers and researchers; monitoring disposal of waste and sewage than can potentially affect the environment, and designing protocols for dealing with the outbreak.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.