Evidence map›Paper›PMID 33043139›Full record

ArticleMedical research archives2020

Plasma and Urinary FGF-2 and VEGF-A Levels Identify Children at Risk for Severe Bleeding after Pediatric Cardiopulmonary Bypass: A Pilot Study.

Anthony A Sochet, Elizabeth A Wilson, Jharna R Das, John T Berger, Patricio E Ray

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical research archives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anthony A SochetDivision of Critical Care Medicine, Department of Pediatrics, Children's National Health System, 111 Michigan Ave NW, Washington, DC 20010.
Elizabeth A WilsonDivision of Critical Care Medicine, Department of Pediatrics, Children's National Health System, 111 Michigan Ave NW, Washington, DC 20010.
Jharna R DasNephrology, Department of Pediatrics, Children's National Health System, 111 Michigan Ave NW, Washington, DC 20010.
John T BergerDivision of Critical Care Medicine, Department of Pediatrics, Children's National Health System, 111 Michigan Ave NW, Washington, DC 20010.
Patricio E RayNephrology, Department of Pediatrics, Children's National Health System, 111 Michigan Ave NW, Washington, DC 20010.
Children's National · US

Funding

Role of bFGF low affinity receptors in childhood HIVANR01DK049419 · NIDDK · UNIVERSITY OF VIRGINIA · PI PATRICIO E. RAY · 1994 to 2026
$7.4M
Role of heparin binding growth factors in vascular leakage and fatal bleedingR01HL102497 · NHLBI · UNIVERSITY OF VIRGINIA · PI RAY, PATRICIO E. · 2009 to 2018
$3.4M
Role of cytokines and APOL-1 in the pathogenesis of childhood HIV associated nephrologyR01DK103564 · NIDDK · UNIVERSITY OF VIRGINIA · PI RAY, PATRICIO E. · 2014 to 2023
$3.0M
Novel mechanisms and Drosophila model of APOL1-HIV-1 nephropathies in childrenR01DK115968 · NIDDK · UNIVERSITY OF VIRGINIA · PI HAN, ZHE, RAY, PATRICIO E. · 2018 to 2022
$2.3M
Pathogenesis of chronic renal injury and hypertension in HIV-infected childrenR01DK108368 · NIDDK · UNIVERSITY OF VIRGINIA · PI RAY, PATRICIO E. · 2015 to 2019
$1.5M
NHLBI NIH HHS R01 HL102497NIDDK NIH HHS R01 DK049419NIDDK NIH HHS R01 DK103564NIDDK NIH HHS R01 DK108368NIDDK NIH HHS R01 DK115968
6 · The paper itself

Abstract

Severe bleeding after cardiothoracic surgery with cardiopulmonary bypass (CPB) is associated with increased morbidity and mortality in adults and children. Fibroblast Growth Factor-2 (FGF-2) and Vascular Endothelial Growth Factor-A (VEGF-A) induce hemorrhage in murine models with heparin exposure. We aim to determine if plasma and urine levels of FGF-2 and VEGF-A in the immediate perioperative period can identify children with severe bleeding after CPB. We performed a prospective, observational biomarker study in 64 children undergoing CPB for congenital heart disease repair from June 2015 - January 2017 in a tertiary pediatric referral center. Primary outcome was severe bleeding defined as ≥ 20% estimated blood volume loss within 24-hours. Independent variables included perioperative plasma and urinary FGF-2 and VEGF-A levels. Analyses included comparative (Wilcoxon rank sum, Fisher's exact, and Student's

Indexed as

bleedingCardiopulmonary bypass surgeryFibroblast Growth Factor 2heparin

Identifiers

PMID33043139
PMCPMC7546309
OpenAlexW3036642963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.