ReviewFrontiers in cell and developmental biology2020
Molecular Mechanisms of Cadherin Function During Cortical Migration.
Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.Nature communications · 2026Article
- Reconstructing single-cell resolution from spatial transcriptomics with CellRefiner.Nature communications · 2026Article
- DifferentialProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Druggable Mendelian randomization prioritizes CDH2 and supports finerenone as a candidate therapeutic strategy for diabetic retinopathy.Frontiers in pharmacology · 2026Article
- Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficientFrontiers in molecular neuroscience · 2026Article
- Cadherin 11 regulates presynaptic vesicle trafficking and neuronal activity in autism-related brain circuit.Molecular psychiatry · 2026Article
- Dmrt2 regulates sex-biased neuronal development in the cingulate cortex.Cellular and molecular life sciences : CMLS · 2025Article
- Cadherin-6 controls neuronal migration during mouse neocortical development via an integrin-mediated pathway.The FEBS journal · 2025Article
- Human-specific genomic evolution of a regulatory network enables fine-tuning of N-cadherin gene expression.Cellular and molecular life sciences : CMLS · 2025Article
- Biofunctionalized gelatin hydrogels support development and maturation of iPSC-derived cortical organoids.Cell reports · 2024Article
- Hsa-microRNA-1249-3p/Homeobox A13 axis modulates the expression of β-catenin gene in human epithelial cells.Scientific reports · 2023Article
- Article
- Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window.bioRxiv : the preprint server for biology · 2023Article
- Ethanol-induced transcriptional and translational changes in Aldh1l1-Egfp/Rpl10a cortical astrocyte cultures.Frontiers in neuroscience · 2023Article
- Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window.Frontiers in neural circuits · 2023Article
- Article
- Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population.Frontiers in genetics · 2022Article
- Flying under the radar: CDH2 (N-cadherin), an important hub molecule in neurodevelopmental and neurodegenerative diseases.Frontiers in neuroscience · 2022Review
- Cadherins in early neural development.Cellular and molecular life sciences : CMLS · 2021Review
- Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development of the cerebral cortex, different types of neurons migrate from distinct origins to create the different cortical layers and settle within them. Along their way, migrating neurons use cell adhesion molecules on their surface to interact with other cells that will play critical roles to ensure that migration is successful. Radially migrating projection neurons interact primarily with radial glia and Cajal-Retzius cells, whereas interneurons originating in the subpallium follow a longer, tangential route and encounter additional cellular substrates before reaching the cortex. Cell-cell adhesion is therefore essential for the correct migration of cortical neurons. Several members of the cadherin superfamily of cell adhesion proteins, which mediate cellular interactions through calcium-dependent, mostly homophilic binding, have been shown to play important roles during neuronal migration of both projection neurons and interneurons. Although several classical cadherins and protocadherins are involved in this process, the most prominent is CDH2. This mini review will explore the cellular and molecular mechanisms underpinning cadherin function during cortical migration, including recent advances in our understanding of the control of adhesive strength through regulation of cadherin surface levels.
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