ReviewFrontiers in cell and developmental biology2020
FLRTing Neurons in Cortical Migration During Cerebral Cortex Development.
Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.Nature communications · 2026Article
- Deciphering epileptogenic and activity-dependent gene programs in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Sex-dimorphic reprogramming of fetal mouse brain development by maternal estradiol excess.Biology of sex differences · 2025Article
- Reconstitution of synaptic junctions orchestrated by teneurin-latrophilin complexes.Science (New York, N.Y.) · 2025Article
- Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis.Frontiers in endocrinology · 2025Article
- Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis.Nature communications · 2024Article
- Editorial: Molecular and Cellular Crosstalk on Neuronal Functionality and Regulation, From Development to Pathology.Frontiers in molecular neuroscience · 2022Article
- Expression of FLRT2 in Postnatal Central Nervous System Development and After Spinal Cord Injury.Frontiers in molecular neuroscience · 2021Article
- Involvement of Netrins and Their Receptors in Neuronal Migration in the Cerebral Cortex.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development, two coordinated events shape the morphology of the mammalian cerebral cortex, leading to the cortex's columnar and layered structure: the proliferation of neuronal progenitors and cortical migration. Pyramidal neurons originating from germinal zones migrate along radial glial fibers to their final position in the cortical plate by both radial migration and tangential dispersion. These processes rely on the delicate balance of intercellular adhesive and repulsive signaling that takes place between neurons interacting with different substrates and guidance cues. Here, we focus on the function of the cell adhesion molecules fibronectin leucine-rich repeat transmembrane proteins (FLRTs) in regulating both the radial migration of neurons, as well as their tangential spread, and the impact these processes have on cortex morphogenesis. In combining structural and functional analysis, recent studies have begun to reveal how FLRT-mediated responses are precisely tuned - from forming different protein complexes to modulate either cell adhesion or repulsion in neurons. These approaches provide a deeper understanding of the context-dependent interactions of FLRTs with multiple receptors involved in axon guidance and synapse formation that contribute to finely regulated neuronal migration.
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Registered trials
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