ArticleFrontiers in cell and developmental biology2020
C2C12 Mouse Myoblasts Damage Induced by Oxidative Stress Is Alleviated by the Antioxidant Capacity of the Active Substance Phloretin.
Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Sporoderm Disruption Reshapes the Chemical Characteristics and Enhances the Mitochondrial Protective Activity ofInternational journal of molecular sciences · 2026Article
- Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges.Advanced healthcare materials · 2026Review
- Phloretin inhibits ferroptosis by restoring the antioxidant capacity of bovine adipose and muscle cells via the AMPK-PPAR signaling pathway.Stress biology · 2025Article
- Sea Vegetables and Fruits as Novel Dietary Protective Factors for Sarcopenia and Muscle Function in Taiwan: A Cross-Sectional Study.Nutrients · 2025Article
- Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Human adipose-derived stem cell exosomes reduce mitochondrial DNA common deletion through PINK1/Parkin-mediated mitophagy to improve skin photoaging.Stem cell research & therapy · 2025Article
- Microneedles with Implantable Tip-Accumulated Therapeutics for the Long-Term Management of Psoriasis.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Effect of HY7602 Fermented Deer Antler on Physical Fatigue and Antioxidant Activity in Mice.International journal of molecular sciences · 2024Article
- Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways.Antioxidants (Basel, Switzerland) · 2024Review
- Valine improves mitochondrial function and protects against oxidative stress.Bioscience, biotechnology, and biochemistry · 2024Article
- Exploring the Role of Oxidative Stress in Skeletal Muscle Atrophy: Mechanisms and Implications.Cureus · 2023Review
- Phloroglucinol Inhibits Oxidative-Stress-Induced Cytotoxicity in C2C12 Murine Myoblasts through Nrf-2-Mediated Activation of HO-1.International journal of molecular sciences · 2023Article
- Bioactive Substances and Biological Functions inMolecules (Basel, Switzerland) · 2023Review
- Article
- Chromium Flavonoid Complexation in an Antioxidant Capacity Role.International journal of molecular sciences · 2022Article
- Protective Effect of Phloretin against Hydrogen Peroxide-Induced Oxidative Damage by Enhancing Autophagic Flux in DF-1 Cells.Oxidative medicine and cellular longevity · 2022Article
- Antioxidant Properties and Cytoprotective Effect ofAntioxidants (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A new direction for the treatment of skeletal myopathies, which are mainly caused by abnormal mitochondrial metabolism, is the application of drugs and active substances to relieve oxidative stress in mitochondria. Phloretin, a dihydrochalcone active substance widely present in succulent fruits, has attracted attention for its strong antioxidant activity. This study aimed to investigate the potential antioxidant effects of phloretin and its potential mechanism of action in C2C12 mouse myoblasts. Under oxidative stress caused by 500 μmol/L H
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