Evidence map›Paper›PMID 33042963›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug Response.

Hemamylammal Sivakumar, Mahesh Devarasetty, David E Kram, Roy E Strowd, Aleksander Skardal

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  7. Interaction of NF-κB and FOSL1 drives glioma stemness.Cellular and molecular life sciences : CMLS · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hemamylammal SivakumarDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United States.
Mahesh DevarasettyWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
David E KramSection of Pediatric Hematology and Oncology, Department of Pediatrics, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC, United States.
Roy E StrowdComprehensive Cancer Center at Wake Forest Baptist Medical, Winston-Salem, NC, United States.
Aleksander SkardalDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United States.

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Predicting Tumor Heterogeneity Evolution After Therapy In Patient-Derived Ex Vivo Glioblastoma OrganoidsR21CA229027 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SKARDAL, ALEKSANDER, STROWD, ROY ERVIN · 2018 to 2019
$597k
NCATS NIH HHS UL1 TR001420NCI NIH HHS R21 CA229027
6 · The paper itself

Abstract

Glioblastoma (GBM) is a lethal, incurable form of cancer in the brain. Even with maximally aggressive surgery and chemoradiotherapy, median patient survival is 14.5 months. These tumors infiltrate normal brain tissue, are surgically incurable, and universally recur. GBMs are characterized by genetic, epigenetic, and microenvironmental heterogeneity, and they evolve spontaneously over time and as a result of treatment. However, tracking such heterogeneity in real time in response to drug treatments has been impossible. Here we describe the development of an

Indexed as

drug responseglioblastomaorganoidspheroidtumor heterogeneity

Identifiers

PMID33042963
PMCPMC7523412

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.