ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Enhancing Exercise Performance Under Hypoxia: A Network Meta-Analysis and Animal Experimental Validation of Plant Bioactive Compounds.Nutrients · 2026Article
- Intermittent fasting and exercise: a dual intervention for orchestrating glycolipid conversion and utilization in healthy mice.Molecular and cellular biochemistry · 2025Article
- Article
- Long-Term Dietary Consumption of Grapes Alters Phenotypic Expression in Skeletal Muscle of Aged Male and Female Mice.Foods (Basel, Switzerland) · 2025Article
- Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity.Nature metabolism · 2025Article
- Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms.Metabolites · 2024Review
- Transcriptional control of metabolism by interferon regulatory factors.Nature reviews. Endocrinology · 2024Review
- Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication.The Journal of clinical investigation · 2024Article
- Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis.Nature communications · 2023Article
- Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Metabolic, fibrotic and splicing pathways are all altered in Emery-Dreifuss muscular dystrophy spectrum patients to differing degrees.Human molecular genetics · 2023Article
- Protein Targeting to Glycogen (PTG): A Promising Player in Glucose and Lipid Metabolism.Biomolecules · 2022Review
- Review
- Skeletal Muscle CSE Deficiency Leads to Insulin Resistance in Mice.Antioxidants (Basel, Switzerland) · 2022Article
- Article
- PARP1 inhibition enhances reactive oxygen species on gut microbiota.Journal of cellular physiology · 2022Article
- Plasma Metabolomics Reveals β-Glucan Improves Muscle Strength and Exercise Capacity in Athletes.Metabolites · 2022Article
- IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Exercise-induced fatigue and exhaustion are interesting areas for many researchers. Muscle glycogen is critical for physical performance. However, how glycogen metabolism is manipulated during exercise is not very clear. The aim here is to assess the impact of interferon regulatory factor 4 (IRF4) on skeletal muscle glycogen and subsequent regulation of exercise capacity. Skeletal muscle-specific IRF4 knockout mice show normal body weight and insulin sensitivity, but better exercise capacity and increased glycogen content with unaltered triglyceride levels compared to control mice on chow diet. In contrast, mice overexpression of IRF4 displays decreased exercise capacity and lower glycogen content. Mechanistically, IRF4 regulates glycogen-associated regulatory subunit protein targeting to glycogen (PTG) to manipulate glucose metabolism in skeletal muscle. Knockdown of PTG can reverse the effects imposed by the absence of IRF4 in vivo. These studies reveal a regulatory pathway including IRF4/PTG/glycogen synthesis on controlling exercise capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.